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Clinically relevant benzoxaboroles inhibit mRNA processing in Trypanosoma brucei

OBJECTIVE: The cleavage and polyadenylation endonuclease CPSF73 is thought to be the target of the anti-trypanosomal benzoxaboroles AN7973, acoziborole and AN11736. We previously showed that AN7973 inhibits mRNA processing. We here investigated whether the drug candidates acoziborole (for human slee...

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Detalles Bibliográficos
Autores principales:	Waithaka, Albina, Clayton, Christine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research Note
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9758897/ https://www.ncbi.nlm.nih.gov/pubmed/36528767 http://dx.doi.org/10.1186/s13104-022-06258-y

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