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Functional connectivity in behavioral variant frontotemporal dementia
INTRODUCTION: Functional connectivity (FC)—which reflects relationships between neural activity in different brain regions—has been used to explore the functional architecture of the brain in neurodegenerative disorders. Although an increasing number of studies have explored FC changes in behavioral...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9759144/ https://www.ncbi.nlm.nih.gov/pubmed/36306386 http://dx.doi.org/10.1002/brb3.2790 |
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author | Ferreira, Luiz Kobuti Lindberg, Olof Santillo, Alexander F Wahlund, Lars‐Olof |
author_facet | Ferreira, Luiz Kobuti Lindberg, Olof Santillo, Alexander F Wahlund, Lars‐Olof |
author_sort | Ferreira, Luiz Kobuti |
collection | PubMed |
description | INTRODUCTION: Functional connectivity (FC)—which reflects relationships between neural activity in different brain regions—has been used to explore the functional architecture of the brain in neurodegenerative disorders. Although an increasing number of studies have explored FC changes in behavioral variant frontotemporal dementia (bvFTD), there is no focused, in‐depth review about FC in bvFTD. METHODS: Comprehensive literature search and narrative review to summarize the current field of FC in bvFTD. RESULTS: (1) Decreased FC within the salience network (SN) is the most consistent finding in bvFTD; (2) FC changes extend beyond the SN and affect the interplay between networks; (3) results within the Default Mode Network are mixed; (4) the brain as a network is less interconnected and less efficient in bvFTD; (5) symptoms, functional impairment, and cognition are associated with FC; and (6) the functional architecture resembles patterns of neuropathological spread. CONCLUSIONS: FC has potential as a biomarker, and future studies are expected to advance the field with multicentric initiatives, longitudinal designs, and methodological advances. |
format | Online Article Text |
id | pubmed-9759144 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97591442022-12-20 Functional connectivity in behavioral variant frontotemporal dementia Ferreira, Luiz Kobuti Lindberg, Olof Santillo, Alexander F Wahlund, Lars‐Olof Brain Behav Reviews INTRODUCTION: Functional connectivity (FC)—which reflects relationships between neural activity in different brain regions—has been used to explore the functional architecture of the brain in neurodegenerative disorders. Although an increasing number of studies have explored FC changes in behavioral variant frontotemporal dementia (bvFTD), there is no focused, in‐depth review about FC in bvFTD. METHODS: Comprehensive literature search and narrative review to summarize the current field of FC in bvFTD. RESULTS: (1) Decreased FC within the salience network (SN) is the most consistent finding in bvFTD; (2) FC changes extend beyond the SN and affect the interplay between networks; (3) results within the Default Mode Network are mixed; (4) the brain as a network is less interconnected and less efficient in bvFTD; (5) symptoms, functional impairment, and cognition are associated with FC; and (6) the functional architecture resembles patterns of neuropathological spread. CONCLUSIONS: FC has potential as a biomarker, and future studies are expected to advance the field with multicentric initiatives, longitudinal designs, and methodological advances. John Wiley and Sons Inc. 2022-10-28 /pmc/articles/PMC9759144/ /pubmed/36306386 http://dx.doi.org/10.1002/brb3.2790 Text en © 2022 The Authors. Brain and Behavior published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Reviews Ferreira, Luiz Kobuti Lindberg, Olof Santillo, Alexander F Wahlund, Lars‐Olof Functional connectivity in behavioral variant frontotemporal dementia |
title | Functional connectivity in behavioral variant frontotemporal dementia |
title_full | Functional connectivity in behavioral variant frontotemporal dementia |
title_fullStr | Functional connectivity in behavioral variant frontotemporal dementia |
title_full_unstemmed | Functional connectivity in behavioral variant frontotemporal dementia |
title_short | Functional connectivity in behavioral variant frontotemporal dementia |
title_sort | functional connectivity in behavioral variant frontotemporal dementia |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9759144/ https://www.ncbi.nlm.nih.gov/pubmed/36306386 http://dx.doi.org/10.1002/brb3.2790 |
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