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Talin variant P229S compromises integrin activation and associates with multifaceted clinical symptoms

Adhesion of cells to the extracellular matrix (ECM) must be exquisitely coordinated to enable development and tissue homeostasis. Cell–ECM interactions are regulated by multiple signalling pathways that coordinate the activation state of the integrin family of ECM receptors. The protein talin is piv...

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Detalles Bibliográficos
Autores principales:	Azizi, Latifeh, Varela, Lorena, Turkki, Paula, Mykuliak, Vasyl V, Korpela, Sanna, Ihalainen, Teemu O, Church, Joseph, Hytönen, Vesa P, Goult, Benjamin T
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9759328/ https://www.ncbi.nlm.nih.gov/pubmed/35861643 http://dx.doi.org/10.1093/hmg/ddac163

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