USP5-Beclin 1 axis overrides p53-dependent senescence and drives Kras-induced tumorigenicity

Non-small cell lung cancers (NSCLC) frequently contain KRAS mutation but retain wild-type TP53. Abundant senescent cells are observed in premalignant but not in malignant tumors derived from the Kras-driven mouse model, suggesting that KRAS oncogenic signaling would have to overcome the intrinsic se...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Juan, Wang, Yang, Luo, Yue, Liu, Yang, Yi, Yong, Li, Jinsong, Pan, Yang, Li, Weiyuxin, You, Wanbang, Hu, Qingyong, Zhao, Zhiqiang, Zhang, Yujun, Cao, Yang, Zhang, Lingqiang, Yuan, Junying, Xiao, Zhi-Xiong Jim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9759531/
https://www.ncbi.nlm.nih.gov/pubmed/36528652
http://dx.doi.org/10.1038/s41467-022-35557-y

Ejemplares similares

Ejemplares similares