Cargando…

Added value of histogram analysis of ADC in predicting radiation-induced temporal lobe injury of patients with nasopharyngeal carcinoma treated by intensity-modulated radiotherapy

BACKGROUND: This study evaluated the predictive potential of histogram analysis derived from apparent diffusion coefficient (ADC) maps in radiation-induced temporal lobe injury (RTLI) of nasopharyngeal carcinoma (NPC) after intensity-modulated radiotherapy (IMRT). RESULTS: Pretreatment diffusion-wei...

Descripción completa

Detalles Bibliográficos
Autores principales: Bao, Dan, Zhao, Yanfeng, Wu, Wenli, Zhong, Hongxia, Yuan, Meng, Li, Lin, Lin, Meng, Zhao, Xinming, Luo, Dehong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9759610/
https://www.ncbi.nlm.nih.gov/pubmed/36528686
http://dx.doi.org/10.1186/s13244-022-01338-w
_version_ 1784852270669627392
author Bao, Dan
Zhao, Yanfeng
Wu, Wenli
Zhong, Hongxia
Yuan, Meng
Li, Lin
Lin, Meng
Zhao, Xinming
Luo, Dehong
author_facet Bao, Dan
Zhao, Yanfeng
Wu, Wenli
Zhong, Hongxia
Yuan, Meng
Li, Lin
Lin, Meng
Zhao, Xinming
Luo, Dehong
author_sort Bao, Dan
collection PubMed
description BACKGROUND: This study evaluated the predictive potential of histogram analysis derived from apparent diffusion coefficient (ADC) maps in radiation-induced temporal lobe injury (RTLI) of nasopharyngeal carcinoma (NPC) after intensity-modulated radiotherapy (IMRT). RESULTS: Pretreatment diffusion-weighted imaging (DWI) of the temporal lobes of 214 patients with NPC was retrospectively analyzed to obtain ADC histogram parameters. Of the 18 histogram parameters derived from ADC maps, 7 statistically significant variables in the univariate analysis were included in the multivariate logistic regression analysis. The final best prediction model selected by backward stepwise elimination with Akaike information criteria as the stopping rule included kurtosis, maximum energy, range, and total energy. A Rad-score was established by combining the four variables, and it provided areas under the curve (AUCs) of 0.95 (95% confidence interval [CI] 0.91–0.98) and 0.89 (95% CI 0.81–0.97) in the training and validation cohorts, respectively. The combined model, integrating the Rad-score with the T stage (p = 0.02), showed a favorable prediction performance in the training and validation cohorts (AUC = 0.96 and 0.87, respectively). The calibration curves showed a good agreement between the predicted and actual RTLI occurrences. CONCLUSIONS: Pretreatment histogram analysis of ADC maps and their combination with the T stage showed a satisfactory ability to predict RTLI in NPC after IMRT. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13244-022-01338-w.
format Online
Article
Text
id pubmed-9759610
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Springer Vienna
record_format MEDLINE/PubMed
spelling pubmed-97596102022-12-19 Added value of histogram analysis of ADC in predicting radiation-induced temporal lobe injury of patients with nasopharyngeal carcinoma treated by intensity-modulated radiotherapy Bao, Dan Zhao, Yanfeng Wu, Wenli Zhong, Hongxia Yuan, Meng Li, Lin Lin, Meng Zhao, Xinming Luo, Dehong Insights Imaging Original Article BACKGROUND: This study evaluated the predictive potential of histogram analysis derived from apparent diffusion coefficient (ADC) maps in radiation-induced temporal lobe injury (RTLI) of nasopharyngeal carcinoma (NPC) after intensity-modulated radiotherapy (IMRT). RESULTS: Pretreatment diffusion-weighted imaging (DWI) of the temporal lobes of 214 patients with NPC was retrospectively analyzed to obtain ADC histogram parameters. Of the 18 histogram parameters derived from ADC maps, 7 statistically significant variables in the univariate analysis were included in the multivariate logistic regression analysis. The final best prediction model selected by backward stepwise elimination with Akaike information criteria as the stopping rule included kurtosis, maximum energy, range, and total energy. A Rad-score was established by combining the four variables, and it provided areas under the curve (AUCs) of 0.95 (95% confidence interval [CI] 0.91–0.98) and 0.89 (95% CI 0.81–0.97) in the training and validation cohorts, respectively. The combined model, integrating the Rad-score with the T stage (p = 0.02), showed a favorable prediction performance in the training and validation cohorts (AUC = 0.96 and 0.87, respectively). The calibration curves showed a good agreement between the predicted and actual RTLI occurrences. CONCLUSIONS: Pretreatment histogram analysis of ADC maps and their combination with the T stage showed a satisfactory ability to predict RTLI in NPC after IMRT. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13244-022-01338-w. Springer Vienna 2022-12-17 /pmc/articles/PMC9759610/ /pubmed/36528686 http://dx.doi.org/10.1186/s13244-022-01338-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Bao, Dan
Zhao, Yanfeng
Wu, Wenli
Zhong, Hongxia
Yuan, Meng
Li, Lin
Lin, Meng
Zhao, Xinming
Luo, Dehong
Added value of histogram analysis of ADC in predicting radiation-induced temporal lobe injury of patients with nasopharyngeal carcinoma treated by intensity-modulated radiotherapy
title Added value of histogram analysis of ADC in predicting radiation-induced temporal lobe injury of patients with nasopharyngeal carcinoma treated by intensity-modulated radiotherapy
title_full Added value of histogram analysis of ADC in predicting radiation-induced temporal lobe injury of patients with nasopharyngeal carcinoma treated by intensity-modulated radiotherapy
title_fullStr Added value of histogram analysis of ADC in predicting radiation-induced temporal lobe injury of patients with nasopharyngeal carcinoma treated by intensity-modulated radiotherapy
title_full_unstemmed Added value of histogram analysis of ADC in predicting radiation-induced temporal lobe injury of patients with nasopharyngeal carcinoma treated by intensity-modulated radiotherapy
title_short Added value of histogram analysis of ADC in predicting radiation-induced temporal lobe injury of patients with nasopharyngeal carcinoma treated by intensity-modulated radiotherapy
title_sort added value of histogram analysis of adc in predicting radiation-induced temporal lobe injury of patients with nasopharyngeal carcinoma treated by intensity-modulated radiotherapy
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9759610/
https://www.ncbi.nlm.nih.gov/pubmed/36528686
http://dx.doi.org/10.1186/s13244-022-01338-w
work_keys_str_mv AT baodan addedvalueofhistogramanalysisofadcinpredictingradiationinducedtemporallobeinjuryofpatientswithnasopharyngealcarcinomatreatedbyintensitymodulatedradiotherapy
AT zhaoyanfeng addedvalueofhistogramanalysisofadcinpredictingradiationinducedtemporallobeinjuryofpatientswithnasopharyngealcarcinomatreatedbyintensitymodulatedradiotherapy
AT wuwenli addedvalueofhistogramanalysisofadcinpredictingradiationinducedtemporallobeinjuryofpatientswithnasopharyngealcarcinomatreatedbyintensitymodulatedradiotherapy
AT zhonghongxia addedvalueofhistogramanalysisofadcinpredictingradiationinducedtemporallobeinjuryofpatientswithnasopharyngealcarcinomatreatedbyintensitymodulatedradiotherapy
AT yuanmeng addedvalueofhistogramanalysisofadcinpredictingradiationinducedtemporallobeinjuryofpatientswithnasopharyngealcarcinomatreatedbyintensitymodulatedradiotherapy
AT lilin addedvalueofhistogramanalysisofadcinpredictingradiationinducedtemporallobeinjuryofpatientswithnasopharyngealcarcinomatreatedbyintensitymodulatedradiotherapy
AT linmeng addedvalueofhistogramanalysisofadcinpredictingradiationinducedtemporallobeinjuryofpatientswithnasopharyngealcarcinomatreatedbyintensitymodulatedradiotherapy
AT zhaoxinming addedvalueofhistogramanalysisofadcinpredictingradiationinducedtemporallobeinjuryofpatientswithnasopharyngealcarcinomatreatedbyintensitymodulatedradiotherapy
AT luodehong addedvalueofhistogramanalysisofadcinpredictingradiationinducedtemporallobeinjuryofpatientswithnasopharyngealcarcinomatreatedbyintensitymodulatedradiotherapy