Cargando…

Genomic characterization reveals distinct mutation landscapes and therapeutic implications in neuroendocrine carcinomas of the gastrointestinal tract

BACKGROUND: Neuroendocrine carcinomas of the gastrointestinal tract (GI‐NECs) remain a disease of grim prognosis with limited therapeutic options. Their molecular characteristics are still undefined. This study aimed to explore the underlying genetic basis and heterogeneity of GI‐NECs. METHODS: Comp...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Huanwen, Yu, Zicheng, Liu, Yueping, Guo, Lei, Teng, Lianghong, Guo, Lingchuan, Liang, Li, Wang, Jing, Gao, Jie, Li, Ruiyu, Yang, Ling, Nie, Xiu, Su, Dan, Liang, Zhiyong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9759768/ https://www.ncbi.nlm.nih.gov/pubmed/36264285 http://dx.doi.org/10.1002/cac2.12372

Ejemplares similares

p53 Immunohistochemistry Patterns Are Surrogate Biomarkers for TP53 Mutations in Gastrointestinal Neuroendocrine Neoplasms
por: Li, Junjie, et al.
Publicado: (2021)

A novel cuproptosis-related gene model predicts outcomes and treatment responses in pancreatic adenocarcinoma
por: Liu, Qixian, et al.
Publicado: (2023)

Identification and Validation of Immune Molecular Subtypes in Pancreatic Ductal Adenocarcinoma: Implications for Prognosis and Immunotherapy
por: Li, Ruiyu, et al.
Publicado: (2021)

Mixed Neuroendocrine Non-Neuroendocrine Neoplasms of the Gastrointestinal Tract: A Case Series
por: Guerrera, Luigi Pio, et al.
Publicado: (2022)

Gastrointestinal Goblet Cell Adenocarcinomas Harbor Distinctive Clinicopathological, Immune, and Genomic Landscape
por: Lin, Dong-Liang, et al.
Publicado: (2021)

Distinct mutational backgrounds and clonal architectures implicated prognostic discrepancies in small-cell carcinomas of the esophagus and lung
por: Song, Zhengbo, et al.
Publicado: (2021)

Neuroendocrine Neoplasms of the Gastrointestinal Tract versus Neuroendocrine Neoplasms of the Gynaecological Tract—Comparison of the Risk Factors and Non-Surgical Treatment Efficacy
por: Lorenz, Anna, et al.
Publicado: (2023)

Bacteriophages in the gastrointestinal tract and their implications
por: Łusiak-Szelachowska, Marzanna, et al.
Publicado: (2017)

Clinical Application of MicroRNA Testing in Neuroendocrine Tumors of the Gastrointestinal Tract
por: Vicentini, Caterina, et al.
Publicado: (2014)

Molecular factors, diagnosis and management of gastrointestinal tract neuroendocrine tumors: An update
por: Pavlidis, Efstathios Theodoros, et al.
Publicado: (2022)

Whole-genome sequencing reveals distinct genetic bases for insulinomas and non-functional pancreatic neuroendocrine tumours: leading to a new classification system
por: Hong, Xiafei, et al.
Publicado: (2020)

Contemporary methods of therapy and follow-up of neuroendocrine tumours of the gastrointestinal tract and the pancreas
por: Gut, Paweł, et al.
Publicado: (2012)

Neuroendocrine carcinoma in the extrahepatic biliary tract: A case report and literature review
por: Zhang, Liang, et al.
Publicado: (2018)

Multi‐omics analysis of intra‐tumoural and inter‐tumoural heterogeneity in pancreatic ductal adenocarcinoma
por: Liu, Xiaoqian, et al.
Publicado: (2022)

Hobnail variant of papillary thyroid carcinoma: molecular profiling and comparison to classical papillary thyroid carcinoma, poorly differentiated thyroid carcinoma and anaplastic thyroid carcinoma
por: Teng, Lianghong, et al.
Publicado: (2017)

Racial/Ethnic Disparities and Survival Characteristics in Non-Pancreatic Gastrointestinal Tract Neuroendocrine Tumors
por: Goksu, Suleyman Yasin, et al.
Publicado: (2020)

Editorial: Neuroendocrine tumors of the gastrointestinal tract, liver, and pancreas: current management and treatment strategies
por: Giakoustidis, Alexandros, et al.
Publicado: (2023)

Comprehensive analysis of oncogenic fusions in mismatch repair deficient colorectal carcinomas by sequential DNA and RNA next generation sequencing
por: Wang, Jing, et al.
Publicado: (2021)

Do neuroendocrine carcinomas and mixed neuroendocrine–non-neuroendocrine neoplasm of the gastrointestinal tract have the same prognosis? A SEER database analysis of 12,878 cases
por: Shi, Huiying, et al.
Publicado: (2020)

Epigenetic landscape of pancreatic neuroendocrine tumours reveals distinct cells of origin and means of tumour progression
por: Di Domenico, Annunziata, et al.
Publicado: (2020)

The long noncoding RNA landscape of neuroendocrine prostate cancer and its clinical implications
por: Ramnarine, Varune Rohan, et al.
Publicado: (2018)

Reconstruction and Visualization of Human Gastrointestinal Tract
por: Yan, Rong-guo, et al.
Publicado: (2012)

Clinicopathological Features of Primary Neuroendocrine Tumors of Gastrointestinal/Pancreatobiliary Tract With Emphasis on High-Grade (Grade 3) Well-Differentiated Neuroendocrine Tumors
por: Hashmi, Atif A, et al.
Publicado: (2021)

Nationwide registry for patients with neuroendocrine neoplasm of pancreas, gastrointestinal tract, lungs, bronchi, or thymus in Japan
por: Masui, Toshihiko, et al.
Publicado: (2022)

Distinct stages during colonization of the mouse gastrointestinal tract by Candida albicans
por: Prieto, Daniel, et al.
Publicado: (2015)

Genomic Profiling Reveals the Molecular Landscape of Gastrointestinal Tract Cancers in Chinese Patients
por: Zhu, Chunrong, et al.
Publicado: (2021)

Nomogram for preoperative estimation of histologic grade in gastrointestinal neuroendocrine tumors
por: Wu, Zhi-Qi, et al.
Publicado: (2022)

Histopathology of gastrointestinal neuroendocrine neoplasms
por: Hirabayashi, Kenichi, et al.
Publicado: (2013)

Gastrointestinal neuroendocrine tumors in 2020
por: Ahmed, Monjur
Publicado: (2020)

Management of Gastrointestinal Neuroendocrine Tumors
por: Wang, Rongzhi, et al.
Publicado: (2019)

Distinct landscapes of deleterious variants in DNA damage repair system in ethnic human populations
por: Qin, Zixin, et al.
Publicado: (2022)

Neuroendocrine Neoplasms of the Gynecologic Tract
por: Virarkar, Mayur, et al.
Publicado: (2022)

The Mutational, Prognostic, and Therapeutic Landscape of Neuroendocrine Neoplasms
por: Liu, Man, et al.
Publicado: (2023)

Bacterial Community Mapping of the Mouse Gastrointestinal Tract
por: Gu, Shenghua, et al.
Publicado: (2013)

The Landscape of Interactions between Hypoxia-Inducible Factors and Reactive Oxygen Species in the Gastrointestinal Tract
por: Shao, Yirui, et al.
Publicado: (2021)

Whole-exome mutational landscape of neuroendocrine carcinomas of the gallbladder
por: Liu, Fatao, et al.
Publicado: (2021)

Metabolism, Physiological Role, and Clinical Implications of Sphingolipids in Gastrointestinal Tract
por: Kurek, Krzysztof, et al.
Publicado: (2013)

Alcohol Use and Cancers of the Gastrointestinal Tract. Epidemiology and Preventive Implications
por: Rehm, Jürgen, et al.
Publicado: (2020)

Molecular genetic studies on EGFR, KRAS, BRAF, ALK, PIK3CA, PDGFRA, and DDR2 in primary pulmonary adenoid cystic carcinoma
por: Huo, Zhen, et al.
Publicado: (2015)

Genomic dissection of gastrointestinal and lung neuroendocrine neoplasm
por: Wang, Haixing, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_iqbdk3680brlh2frbuaqva5ni8