Ascorbic Acid-Mediated Modulation of Antibiotic Susceptibility of Major Bovine Mastitis Pathogens

This study aimed to investigate the effects of ascorbic acid on antibiotic susceptibility of major bovine mastitis pathogens, including Staphylococcus aureus, Streptococcus dysgalactiae, Streptococcus uberis, Streptococcus agalactiae, and Escherichia coli. Minimum inhibitory concentrations (MICs) we...

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Autores principales: Liang, Zeyi, Shen, Jiahao, Liu, Jing, Li, Qinfan, Yang, Feng, Ding, Xuezhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9759972/
https://www.ncbi.nlm.nih.gov/pubmed/36540100
http://dx.doi.org/10.2147/IDR.S388023
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author Liang, Zeyi
Shen, Jiahao
Liu, Jing
Li, Qinfan
Yang, Feng
Ding, Xuezhi
author_facet Liang, Zeyi
Shen, Jiahao
Liu, Jing
Li, Qinfan
Yang, Feng
Ding, Xuezhi
author_sort Liang, Zeyi
collection PubMed
description This study aimed to investigate the effects of ascorbic acid on antibiotic susceptibility of major bovine mastitis pathogens, including Staphylococcus aureus, Streptococcus dysgalactiae, Streptococcus uberis, Streptococcus agalactiae, and Escherichia coli. Minimum inhibitory concentrations (MICs) were determined by E-test method. The presence of 10 mM ascorbic acid decreased the MICs of penicillin and ampicillin while increased the MICs of erythromycin, kanamycin, streptomycin, and ciprofloxacin for all tested strains. Besides, ascorbic acid specifically reduced the MICs of tetracycline for gram-positive bacteria and chloramphenicol for gram-negative bacteria. This study highlights that ascorbic acid is a potential modulator of antibiotic activity against the major bovine mastitis pathogens.
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spelling pubmed-97599722022-12-19 Ascorbic Acid-Mediated Modulation of Antibiotic Susceptibility of Major Bovine Mastitis Pathogens Liang, Zeyi Shen, Jiahao Liu, Jing Li, Qinfan Yang, Feng Ding, Xuezhi Infect Drug Resist Short Report This study aimed to investigate the effects of ascorbic acid on antibiotic susceptibility of major bovine mastitis pathogens, including Staphylococcus aureus, Streptococcus dysgalactiae, Streptococcus uberis, Streptococcus agalactiae, and Escherichia coli. Minimum inhibitory concentrations (MICs) were determined by E-test method. The presence of 10 mM ascorbic acid decreased the MICs of penicillin and ampicillin while increased the MICs of erythromycin, kanamycin, streptomycin, and ciprofloxacin for all tested strains. Besides, ascorbic acid specifically reduced the MICs of tetracycline for gram-positive bacteria and chloramphenicol for gram-negative bacteria. This study highlights that ascorbic acid is a potential modulator of antibiotic activity against the major bovine mastitis pathogens. Dove 2022-12-14 /pmc/articles/PMC9759972/ /pubmed/36540100 http://dx.doi.org/10.2147/IDR.S388023 Text en © 2022 Liang et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Short Report
Liang, Zeyi
Shen, Jiahao
Liu, Jing
Li, Qinfan
Yang, Feng
Ding, Xuezhi
Ascorbic Acid-Mediated Modulation of Antibiotic Susceptibility of Major Bovine Mastitis Pathogens
title Ascorbic Acid-Mediated Modulation of Antibiotic Susceptibility of Major Bovine Mastitis Pathogens
title_full Ascorbic Acid-Mediated Modulation of Antibiotic Susceptibility of Major Bovine Mastitis Pathogens
title_fullStr Ascorbic Acid-Mediated Modulation of Antibiotic Susceptibility of Major Bovine Mastitis Pathogens
title_full_unstemmed Ascorbic Acid-Mediated Modulation of Antibiotic Susceptibility of Major Bovine Mastitis Pathogens
title_short Ascorbic Acid-Mediated Modulation of Antibiotic Susceptibility of Major Bovine Mastitis Pathogens
title_sort ascorbic acid-mediated modulation of antibiotic susceptibility of major bovine mastitis pathogens
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9759972/
https://www.ncbi.nlm.nih.gov/pubmed/36540100
http://dx.doi.org/10.2147/IDR.S388023
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