Brain Targeting of Citicoline Sodium via Hyaluronic Acid-Decorated Novel Nano-Transbilosomes for Mitigation of Alzheimer’s Disease in a Rat Model: Formulation, Optimization, in vitro and in vivo Assessment

BACKGROUND: Alzheimer’s disease (AD) is one of the furthermost advanced neurodegenerative disorders resulting in cognitive and behavioral impairment. Citicoline sodium (CIT) boosts the brain’s secretion of acetylcholine, which aids in membrane regeneration and repair. However, it suffers from poor b...

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Detalles Bibliográficos
Autores principales: AbouElhassan, Kariman M, Sarhan, Hatem A, Hussein, Amal K, Taye, Ashraf, Ahmed, Yasmin M, Safwat, Mohamed A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9759982/
https://www.ncbi.nlm.nih.gov/pubmed/36540376
http://dx.doi.org/10.2147/IJN.S381353

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