A no-Wnt situation for alveolar macrophage self-renewal

Alveolar macrophages (AMs) are central to defense against respiratory pathogens. Impediments in restoring AMs after infection increase the risk for superinfection, which is associated with significant morbidity and mortality worldwide. In this issue of Immunity, Zhu et al. report a Wnt-β-catenin-HIF...

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Detalles Bibliográficos
Autores principales: Suber, Tomeka, Camiolo, Matthew J., Ray, Anuradha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9759997/
https://www.ncbi.nlm.nih.gov/pubmed/34107266
http://dx.doi.org/10.1016/j.immuni.2021.05.013
Descripción
Sumario:Alveolar macrophages (AMs) are central to defense against respiratory pathogens. Impediments in restoring AMs after infection increase the risk for superinfection, which is associated with significant morbidity and mortality worldwide. In this issue of Immunity, Zhu et al. report a Wnt-β-catenin-HIF-1α axis in AMs that promotes an inflammatory phenotype while restricting proliferation and self-renewal.

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