A no-Wnt situation for alveolar macrophage self-renewal

Alveolar macrophages (AMs) are central to defense against respiratory pathogens. Impediments in restoring AMs after infection increase the risk for superinfection, which is associated with significant morbidity and mortality worldwide. In this issue of Immunity, Zhu et al. report a Wnt-β-catenin-HIF...

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Autores principales: Suber, Tomeka, Camiolo, Matthew J., Ray, Anuradha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9759997/
https://www.ncbi.nlm.nih.gov/pubmed/34107266
http://dx.doi.org/10.1016/j.immuni.2021.05.013
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author Suber, Tomeka
Camiolo, Matthew J.
Ray, Anuradha
author_facet Suber, Tomeka
Camiolo, Matthew J.
Ray, Anuradha
author_sort Suber, Tomeka
collection PubMed
description Alveolar macrophages (AMs) are central to defense against respiratory pathogens. Impediments in restoring AMs after infection increase the risk for superinfection, which is associated with significant morbidity and mortality worldwide. In this issue of Immunity, Zhu et al. report a Wnt-β-catenin-HIF-1α axis in AMs that promotes an inflammatory phenotype while restricting proliferation and self-renewal.
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spelling pubmed-97599972022-12-19 A no-Wnt situation for alveolar macrophage self-renewal Suber, Tomeka Camiolo, Matthew J. Ray, Anuradha Immunity Preview Alveolar macrophages (AMs) are central to defense against respiratory pathogens. Impediments in restoring AMs after infection increase the risk for superinfection, which is associated with significant morbidity and mortality worldwide. In this issue of Immunity, Zhu et al. report a Wnt-β-catenin-HIF-1α axis in AMs that promotes an inflammatory phenotype while restricting proliferation and self-renewal. Elsevier Inc. 2021-06-08 2021-06-08 /pmc/articles/PMC9759997/ /pubmed/34107266 http://dx.doi.org/10.1016/j.immuni.2021.05.013 Text en © 2021 Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Preview
Suber, Tomeka
Camiolo, Matthew J.
Ray, Anuradha
A no-Wnt situation for alveolar macrophage self-renewal
title A no-Wnt situation for alveolar macrophage self-renewal
title_full A no-Wnt situation for alveolar macrophage self-renewal
title_fullStr A no-Wnt situation for alveolar macrophage self-renewal
title_full_unstemmed A no-Wnt situation for alveolar macrophage self-renewal
title_short A no-Wnt situation for alveolar macrophage self-renewal
title_sort no-wnt situation for alveolar macrophage self-renewal
topic Preview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9759997/
https://www.ncbi.nlm.nih.gov/pubmed/34107266
http://dx.doi.org/10.1016/j.immuni.2021.05.013
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AT camiolomatthewj nowntsituationforalveolarmacrophageselfrenewal
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