Advances in Single-Cell Sequencing Technology and Its Applications in Triple-Negative Breast Cancer

Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer and is mainly treated with chemotherapy-based combination therapy. In recent years, with the increasing development of global precision medicine, single-cell sequencing (SCS) has become one of the most promising tec...

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Detalles Bibliográficos
Autores principales: Li, Meng, Yan, Tingting, Wang, Miaozhou, Cai, Yanqiu, Wei, Yingyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9760048/
https://www.ncbi.nlm.nih.gov/pubmed/36540278
http://dx.doi.org/10.2147/BCTT.S388534
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author Li, Meng
Yan, Tingting
Wang, Miaozhou
Cai, Yanqiu
Wei, Yingyuan
author_facet Li, Meng
Yan, Tingting
Wang, Miaozhou
Cai, Yanqiu
Wei, Yingyuan
author_sort Li, Meng
collection PubMed
description Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer and is mainly treated with chemotherapy-based combination therapy. In recent years, with the increasing development of global precision medicine, single-cell sequencing (SCS) has become one of the most promising technologies in the field of biotechnology. Moreover, the related application of this technology in TNBC has been applied and developed. By using SCS to study the heterogeneity of TNBC tumor cells, metastasis, drug resistance mechanisms, mutations, and cloning; it can further guide clinical chemotherapy, targeted therapy, and immunotherapy. To further reflect the importance of SCS in TNBC, this paper elaborated on and summarized the research and application progress of SCS in TNBC.
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spelling pubmed-97600482022-12-19 Advances in Single-Cell Sequencing Technology and Its Applications in Triple-Negative Breast Cancer Li, Meng Yan, Tingting Wang, Miaozhou Cai, Yanqiu Wei, Yingyuan Breast Cancer (Dove Med Press) Review Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer and is mainly treated with chemotherapy-based combination therapy. In recent years, with the increasing development of global precision medicine, single-cell sequencing (SCS) has become one of the most promising technologies in the field of biotechnology. Moreover, the related application of this technology in TNBC has been applied and developed. By using SCS to study the heterogeneity of TNBC tumor cells, metastasis, drug resistance mechanisms, mutations, and cloning; it can further guide clinical chemotherapy, targeted therapy, and immunotherapy. To further reflect the importance of SCS in TNBC, this paper elaborated on and summarized the research and application progress of SCS in TNBC. Dove 2022-12-14 /pmc/articles/PMC9760048/ /pubmed/36540278 http://dx.doi.org/10.2147/BCTT.S388534 Text en © 2022 Li et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Li, Meng
Yan, Tingting
Wang, Miaozhou
Cai, Yanqiu
Wei, Yingyuan
Advances in Single-Cell Sequencing Technology and Its Applications in Triple-Negative Breast Cancer
title Advances in Single-Cell Sequencing Technology and Its Applications in Triple-Negative Breast Cancer
title_full Advances in Single-Cell Sequencing Technology and Its Applications in Triple-Negative Breast Cancer
title_fullStr Advances in Single-Cell Sequencing Technology and Its Applications in Triple-Negative Breast Cancer
title_full_unstemmed Advances in Single-Cell Sequencing Technology and Its Applications in Triple-Negative Breast Cancer
title_short Advances in Single-Cell Sequencing Technology and Its Applications in Triple-Negative Breast Cancer
title_sort advances in single-cell sequencing technology and its applications in triple-negative breast cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9760048/
https://www.ncbi.nlm.nih.gov/pubmed/36540278
http://dx.doi.org/10.2147/BCTT.S388534
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