Vaccination of human participants with attenuated Necator americanus hookworm larvae and human challenge in Australia: a dose-finding study and randomised, placebo-controlled, phase 1 trial

BACKGROUND: Control of human hookworm infection would be greatly aided by the development of an effective vaccine. We aimed to develop a live attenuated human hookworm vaccine. METHODS: This was a two-part clinical trial done at Q-Pharm in Brisbane (QLD, Australia) using a live ultraviolet C (UVC)-a...

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Detalles Bibliográficos
Autores principales: Chapman, Paul R, Webster, Rebecca, Giacomin, Paul, Llewellyn, Stacey, Becker, Luke, Pearson, Mark S, De Labastida Rivera, Fabian, O'Rourke, Peter, Engwerda, Christian R, Loukas, Alex, McCarthy, James S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9760122/
https://www.ncbi.nlm.nih.gov/pubmed/34419209
http://dx.doi.org/10.1016/S1473-3099(21)00153-5

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