Enabling online determination of the size-dependent RNA content of lipid nanoparticle-based RNA formulations

The potential of lipid nanoparticles (LNPs) as nucleic acid delivery vehicles has been demonstrated in recent years, culminating in the emergency use approval of LNP-based mRNA SARS-CoV-2 vaccines in late 2020. The determination of RNA content relative to LNP size can be important to the understandi...

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Detalles Bibliográficos
Autores principales: Jia, Xiujuan, Liu, Yong, Wagner, Angela M., Chen, Michelle, Zhao, Yuejie, Smith, Katelyn J., Some, Dan, Abend, Andreas M., Pennington, Justin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier B.V. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9760250/
https://www.ncbi.nlm.nih.gov/pubmed/34741934
http://dx.doi.org/10.1016/j.jchromb.2021.123015

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