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Shapeshifting tau: from intrinsically disordered to paired-helical filaments

Tau is an intrinsically disordered protein that has the ability to self-assemble to form paired helical and straight filaments in Alzheimer’s disease, as well as the ability to form additional distinct tau filaments in other tauopathies. In the presence of microtubules, tau forms an elongated form a...

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Detalles Bibliográficos
Autores principales:	Mengham, Kurtis, Al-Hilaly, Youssra, Oakley, Sebastian, Kasbi, Kamillia, Maina, Mahmoud B., Serpell, Louise C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2022
Materias:	Aging
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9760425/ https://www.ncbi.nlm.nih.gov/pubmed/36373666 http://dx.doi.org/10.1042/EBC20220150

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