Exosomes in Genitourinary Cancers: Emerging Mediators of Drug Resistance and Promising Biomarkers

Drug resistance presents a major obstacle in the treatment of genitourinary cancers. Exosomes as the medium of intercellular communication serve important biological functions and play essential roles in pathological processes, including drug response. Through the transfer of bioactive cargoes, exos...

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Detalles Bibliográficos
Autores principales: Lu, Zeyi, Chen, yuanlei, Luo, Wenqin, Ding, Lifeng, Wang, Huan, Li, Yang, Yang, Bo wen, Ren, Liangliang, Zheng, Qiming, Xie, Haiyun, Wang, Ruyue, Yu, Chenhao, Lin, Yudong, Zhou, Zhenwei, Xia, Liqun, Li, Gonghui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9760437/
https://www.ncbi.nlm.nih.gov/pubmed/36594094
http://dx.doi.org/10.7150/ijbs.78321
Descripción
Sumario:Drug resistance presents a major obstacle in the treatment of genitourinary cancers. Exosomes as the medium of intercellular communication serve important biological functions and play essential roles in pathological processes, including drug response. Through the transfer of bioactive cargoes, exosomes can modulate drug resistance via multiple mechanisms. This review attempts to elucidate the mechanisms of exosomal cargoes with reference to tumor drug resistance, their role in genitourinary cancers, and their potential clinical applications as candidate biomarkers in liquid biopsy.

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