Exosomes in Genitourinary Cancers: Emerging Mediators of Drug Resistance and Promising Biomarkers

Drug resistance presents a major obstacle in the treatment of genitourinary cancers. Exosomes as the medium of intercellular communication serve important biological functions and play essential roles in pathological processes, including drug response. Through the transfer of bioactive cargoes, exos...

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Autores principales: Lu, Zeyi, Chen, yuanlei, Luo, Wenqin, Ding, Lifeng, Wang, Huan, Li, Yang, Yang, Bo wen, Ren, Liangliang, Zheng, Qiming, Xie, Haiyun, Wang, Ruyue, Yu, Chenhao, Lin, Yudong, Zhou, Zhenwei, Xia, Liqun, Li, Gonghui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9760437/
https://www.ncbi.nlm.nih.gov/pubmed/36594094
http://dx.doi.org/10.7150/ijbs.78321
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author Lu, Zeyi
Chen, yuanlei
Luo, Wenqin
Ding, Lifeng
Wang, Huan
Li, Yang
Yang, Bo wen
Ren, Liangliang
Zheng, Qiming
Xie, Haiyun
Wang, Ruyue
Yu, Chenhao
Lin, Yudong
Zhou, Zhenwei
Xia, Liqun
Li, Gonghui
author_facet Lu, Zeyi
Chen, yuanlei
Luo, Wenqin
Ding, Lifeng
Wang, Huan
Li, Yang
Yang, Bo wen
Ren, Liangliang
Zheng, Qiming
Xie, Haiyun
Wang, Ruyue
Yu, Chenhao
Lin, Yudong
Zhou, Zhenwei
Xia, Liqun
Li, Gonghui
author_sort Lu, Zeyi
collection PubMed
description Drug resistance presents a major obstacle in the treatment of genitourinary cancers. Exosomes as the medium of intercellular communication serve important biological functions and play essential roles in pathological processes, including drug response. Through the transfer of bioactive cargoes, exosomes can modulate drug resistance via multiple mechanisms. This review attempts to elucidate the mechanisms of exosomal cargoes with reference to tumor drug resistance, their role in genitourinary cancers, and their potential clinical applications as candidate biomarkers in liquid biopsy.
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spelling pubmed-97604372023-01-01 Exosomes in Genitourinary Cancers: Emerging Mediators of Drug Resistance and Promising Biomarkers Lu, Zeyi Chen, yuanlei Luo, Wenqin Ding, Lifeng Wang, Huan Li, Yang Yang, Bo wen Ren, Liangliang Zheng, Qiming Xie, Haiyun Wang, Ruyue Yu, Chenhao Lin, Yudong Zhou, Zhenwei Xia, Liqun Li, Gonghui Int J Biol Sci Review Drug resistance presents a major obstacle in the treatment of genitourinary cancers. Exosomes as the medium of intercellular communication serve important biological functions and play essential roles in pathological processes, including drug response. Through the transfer of bioactive cargoes, exosomes can modulate drug resistance via multiple mechanisms. This review attempts to elucidate the mechanisms of exosomal cargoes with reference to tumor drug resistance, their role in genitourinary cancers, and their potential clinical applications as candidate biomarkers in liquid biopsy. Ivyspring International Publisher 2023-01-01 /pmc/articles/PMC9760437/ /pubmed/36594094 http://dx.doi.org/10.7150/ijbs.78321 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Lu, Zeyi
Chen, yuanlei
Luo, Wenqin
Ding, Lifeng
Wang, Huan
Li, Yang
Yang, Bo wen
Ren, Liangliang
Zheng, Qiming
Xie, Haiyun
Wang, Ruyue
Yu, Chenhao
Lin, Yudong
Zhou, Zhenwei
Xia, Liqun
Li, Gonghui
Exosomes in Genitourinary Cancers: Emerging Mediators of Drug Resistance and Promising Biomarkers
title Exosomes in Genitourinary Cancers: Emerging Mediators of Drug Resistance and Promising Biomarkers
title_full Exosomes in Genitourinary Cancers: Emerging Mediators of Drug Resistance and Promising Biomarkers
title_fullStr Exosomes in Genitourinary Cancers: Emerging Mediators of Drug Resistance and Promising Biomarkers
title_full_unstemmed Exosomes in Genitourinary Cancers: Emerging Mediators of Drug Resistance and Promising Biomarkers
title_short Exosomes in Genitourinary Cancers: Emerging Mediators of Drug Resistance and Promising Biomarkers
title_sort exosomes in genitourinary cancers: emerging mediators of drug resistance and promising biomarkers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9760437/
https://www.ncbi.nlm.nih.gov/pubmed/36594094
http://dx.doi.org/10.7150/ijbs.78321
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