Strand 1A variant in neuroserpin shows increased aggregation and no loss of inhibition: implication in ameliorating polymerization to retain activity

Neuroserpin (NS) is predominantly expressed in the brain and is the primary inhibitor of tissue plasminogen activator (tPA). NS variants are associated with the neurogenerative disease termed familial encephalopathy with neuroserpin inclusion bodies (FENIB). The disease is characterized by variable...

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Detalles Bibliográficos
Autores principales: Ansari, Shoyab, Ahamad, Shahzaib, Khan, Abdul Burhan, Fatima, Sana, Ahmad, Tahif, Khan, Yasmeen, Gupta, Dinesh, Jairajpuri, Mohamad Aman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2022
Materias:
Molecular Bases of Health & Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9760604/
https://www.ncbi.nlm.nih.gov/pubmed/36408789
http://dx.doi.org/10.1042/BSR20221825

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