A rare loss-of-function genetic mutation suggest a role of dermcidin deficiency in hidradenitis suppurativa pathogenesis

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease with a multifactorial aetiology that involves a strict interplay between genetic factors, immune dysregulation and lifestyle. Familial forms represent around 40% of total HS cases and show an autosomal dominant mode of inheritance...

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Detalles Bibliográficos
Autores principales: Tricarico, Paola Maura, Gratton, Rossella, dos Santos-Silva, Carlos André, de Moura, Ronald Rodrigues, Ura, Blendi, Sommella, Eduardo, Campiglia, Pietro, Del Vecchio, Cecilia, Moltrasio, Chiara, Berti, Irene, D’Adamo, Adamo Pio, Elsherbini, Ahmed M. A., Staudenmaier, Lena, Chersi, Karin, Boniotto, Michele, Krismer, Bernhard, Schittek, Birgit, Crovella, Sergio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9760663/
https://www.ncbi.nlm.nih.gov/pubmed/36544771
http://dx.doi.org/10.3389/fimmu.2022.1060547

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