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Effects of follicle-stimulating hormone on fat metabolism and cognitive impairment in women during menopause

Lipid metabolism disorder is a common pathological manifestation of menopausal women, and is also an important risk factor for many diseases at this stage of life. Epidemiological studies have shown that high levels of follicle-stimulating hormone (FSH) in menopausal women are closely associated wit...

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Autores principales: Mao, Liwei, Wang, Lian, Bennett, Samuel, Xu, Jiake, Zou, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9760686/
https://www.ncbi.nlm.nih.gov/pubmed/36545281
http://dx.doi.org/10.3389/fphys.2022.1043237
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author Mao, Liwei
Wang, Lian
Bennett, Samuel
Xu, Jiake
Zou, Jun
author_facet Mao, Liwei
Wang, Lian
Bennett, Samuel
Xu, Jiake
Zou, Jun
author_sort Mao, Liwei
collection PubMed
description Lipid metabolism disorder is a common pathological manifestation of menopausal women, and is also an important risk factor for many diseases at this stage of life. Epidemiological studies have shown that high levels of follicle-stimulating hormone (FSH) in menopausal women are closely associated with changes in body composition, central obesity, and cognitive decline. Exogenous FSH causes growth and proliferation of adipose, whereas blockage of the FSH signaling pathway leads to decline in adipose. Mechanistically, FSH, FSH receptor (FSHR), G protein coupling, gene mutation and other pathways are involved in adipogenesis and cognitive impairment. Here, we review the critical role and potential interactions of FSH in adipogenesis and cognitive impairment in menopausal women. Further understanding of the exact mechanisms of FSH aggravating obesity and cognitive impairment may provide a new perspective for promoting healthy aging in menopausal women.
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spelling pubmed-97606862022-12-20 Effects of follicle-stimulating hormone on fat metabolism and cognitive impairment in women during menopause Mao, Liwei Wang, Lian Bennett, Samuel Xu, Jiake Zou, Jun Front Physiol Physiology Lipid metabolism disorder is a common pathological manifestation of menopausal women, and is also an important risk factor for many diseases at this stage of life. Epidemiological studies have shown that high levels of follicle-stimulating hormone (FSH) in menopausal women are closely associated with changes in body composition, central obesity, and cognitive decline. Exogenous FSH causes growth and proliferation of adipose, whereas blockage of the FSH signaling pathway leads to decline in adipose. Mechanistically, FSH, FSH receptor (FSHR), G protein coupling, gene mutation and other pathways are involved in adipogenesis and cognitive impairment. Here, we review the critical role and potential interactions of FSH in adipogenesis and cognitive impairment in menopausal women. Further understanding of the exact mechanisms of FSH aggravating obesity and cognitive impairment may provide a new perspective for promoting healthy aging in menopausal women. Frontiers Media S.A. 2022-12-05 /pmc/articles/PMC9760686/ /pubmed/36545281 http://dx.doi.org/10.3389/fphys.2022.1043237 Text en Copyright © 2022 Mao, Wang, Bennett, Xu and Zou. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Mao, Liwei
Wang, Lian
Bennett, Samuel
Xu, Jiake
Zou, Jun
Effects of follicle-stimulating hormone on fat metabolism and cognitive impairment in women during menopause
title Effects of follicle-stimulating hormone on fat metabolism and cognitive impairment in women during menopause
title_full Effects of follicle-stimulating hormone on fat metabolism and cognitive impairment in women during menopause
title_fullStr Effects of follicle-stimulating hormone on fat metabolism and cognitive impairment in women during menopause
title_full_unstemmed Effects of follicle-stimulating hormone on fat metabolism and cognitive impairment in women during menopause
title_short Effects of follicle-stimulating hormone on fat metabolism and cognitive impairment in women during menopause
title_sort effects of follicle-stimulating hormone on fat metabolism and cognitive impairment in women during menopause
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9760686/
https://www.ncbi.nlm.nih.gov/pubmed/36545281
http://dx.doi.org/10.3389/fphys.2022.1043237
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