Cargando…

Pharmacokinetics, absorption, distribution, metabolism and excretion of the MEK inhibitor zapnometinib in rats

Zapnometinib is a MEK inhibitor currently under clinical development for the treatment of COVID-19 and influenza. Zapnometinib has both antiviral and immunomodulatory effects. Information concerning the absorption, distribution, metabolism, and excretion of the compound following single oral doses o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Füll, Yvonne, Wallasch, Christian, Hilton, Ashley, Planz, Oliver
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9760738/ https://www.ncbi.nlm.nih.gov/pubmed/36545320 http://dx.doi.org/10.3389/fphar.2022.1050193

Ejemplares similares

Pharmacokinetics, Pharmacodynamics and Antiviral Efficacy of the MEK Inhibitor Zapnometinib in Animal Models and in Humans
por: Koch-Heier, Julia, et al.
Publicado: (2022)

The MEK1/2 Inhibitor ATR-002 (Zapnometinib) Synergistically Potentiates the Antiviral Effect of Direct-Acting Anti-SARS-CoV-2 Drugs
por: Schreiber, André, et al.
Publicado: (2022)

Pharmacokinetics, Tissue Distribution, Metabolism, and Excretion of Naringin in Aged Rats
por: Zeng, Xuan, et al.
Publicado: (2019)

Pharmacokinetics, Tissue Distribution, and Excretion Characteristics of a Radix Polygoni Multiflori Extract in Rats
por: Cheng, Wenhao, et al.
Publicado: (2022)

Preclinical Absorption, Distribution, Metabolism, and Excretion of Sodium Danshensu, One of the Main Water-Soluble Ingredients in Salvia miltiorrhiza, in Rats
por: Meng, Xiangguo, et al.
Publicado: (2019)

Pharmacokinetics and Excretion of Berberine and Its Nine Metabolites in Rats
por: Feng, Xinchi, et al.
Publicado: (2021)

Pharmacokinetics, Distribution, Metabolism, and Excretion of Omadacycline following a Single Intravenous or Oral Dose of (14)C-Omadacycline in Rats
por: Lin, Wen, et al.
Publicado: (2016)

Pharmacokinetics, distribution, metabolism, and excretion of body-protective compound 157, a potential drug for treating various wounds, in rats and dogs
por: He, Lei, et al.
Publicado: (2022)

Pharmacokinetics, Tissue Distribution and Excretion of Paeonol and Its Major Metabolites in Rats Provide a Further Insight Into Paeonol Effectiveness
por: Hu, Xintong, et al.
Publicado: (2020)

The Pharmacokinetics, Tissue Distribution, Metabolism, and Excretion of Pinostrobin in Rats: Ultra-High-Performance Liquid Chromatography Coupled With Linear Trap Quadrupole Orbitrap Mass Spectrometry Studies
por: Sun, Xiaoya, et al.
Publicado: (2020)

Absorption, tissue distribution, and excretion of glycycoumarin, a major bioactive coumarin from Chinese licorice (Glycyrrhiza uralensis Fisch)
por: Ye, Linhu, et al.
Publicado: (2023)

Absorption, Distribution, Excretion, and Pharmacokinetics of (14)C-Pyronaridine Tetraphosphate in Male and Female Sprague-Dawley Rats
por: Park, Sang Hyun, et al.
Publicado: (2010)

Pharmacokinetics, Bioavailability, Excretion and Metabolism Studies of Akebia Saponin D in Rats: Causes of the Ultra-Low Oral Bioavailability and Metabolic Pathway
por: Li, Pengfei, et al.
Publicado: (2021)

Investigation of in vitro absorption, distribution, metabolism, and excretion and in vivo pharmacokinetics of paromomycin: Influence on oral bioavailability
por: K. Pinjari, M. Jakir S., et al.
Publicado: (2017)

Differences in Multicomponent Pharmacokinetics, Tissue Distribution, and Excretion of Tripterygium Glycosides Tablets in Normal and Adriamycin–Induced Nephrotic Syndrome Rat Models and Correlations With Efficacy and Hepatotoxicity
por: Wu, Wei, et al.
Publicado: (2022)

Pharmacokinetics, Tissue Distribution, Metabolism and Excretion of a Novel COX-2 Inhibitor, Vitacoxib, in Rats
por: Wang, Jianzhong, et al.
Publicado: (2022)

Pharmacokinetics and absorption mechanism of tandospirone citrate
por: Li, Rong, et al.
Publicado: (2023)

Pharmacokinetics, bioavailability, tissue distribution and excretion of tangeretin in rat
por: Hung, Wei-Lun, et al.
Publicado: (2017)

Phase I pharmacokinetic study of an oral, small-molecule MEK inhibitor tunlametinib in patients with advanced NRAS mutant melanoma
por: Zhao, Qian, et al.
Publicado: (2022)

Biliary excretion and pharmacokinetics of several fluoroquinolones after intravenous injection in rabbits
por: SHIMADA, Sumire, et al.
Publicado: (2023)

Absorption, Metabolism, and Excretion of [(14)C]-Tebipenem Pivoxil Hydrobromide (TBP-PI-HBr) in Healthy Male Subjects
por: Gupta, Vipul K., et al.
Publicado: (2023)

Absorption, distribution, metabolism and excretion of molidustat in healthy participants
por: Lentini, Silvia, et al.
Publicado: (2020)

Pharmacokinetic Study of Oral (14)C-Radiolabeled Hyzetimibe, A New Cholesterol Absorption Inhibitor
por: Liao, Jianwei, et al.
Publicado: (2021)

Absorption, distribution, metabolism and excretion of peginesatide, a novel erythropoiesis-stimulating agent, in rats
por: Woodburn, Kathryn W., et al.
Publicado: (2011)

Absorption, Metabolism, and Excretion of ACT-1004-1239, a First-In-Class CXCR7 Antagonist: In Vitro, Preclinical, and Clinical Data
por: Huynh, Christine, et al.
Publicado: (2022)

Absorption, distribution, metabolism, and excretion of [(14)C]‐dasotraline in humans
por: Chen, Yu‐Luan, et al.
Publicado: (2016)

Absorption, Distribution, Metabolism, and Excretion of the Novel Helicase-Primase Inhibitor, Amenamevir (ASP2151), in Rodents
por: Ohtsu, Yoshiaki, et al.
Publicado: (2018)

Comparative pharmacokinetics and urinary excretion of arsenic and mercury after oral administration of realgar, cinnabar and AnGongNiuHuang Pill to rats
por: Wu, Xiao, et al.
Publicado: (2022)

MEK inhibitors as novel host-targeted antivirals with a dual-benefit mode of action against hyperinflammatory respiratory viral diseases
por: Ludwig, Stephan, et al.
Publicado: (2023)

Pharmacokinetics, Tissue Distribution and Excretion of Verticinone from F. hupehensis in Rats
por: Wu, Xiao, et al.
Publicado: (2014)

Metabolic conversion of CI-1040 turns a cellular MEK-inhibitor into an antibacterial compound
por: Bruchhagen, Christin, et al.
Publicado: (2018)

Preclinical characterization of tunlametinib, a novel, potent, and selective MEK inhibitor
por: Liu, Yahong, et al.
Publicado: (2023)

Physiologically Based Pharmacokinetic Modeling to Understand the Absorption of Risperidone Orodispersible Film
por: Chen, Fang, et al.
Publicado: (2020)

Pharmacokinetics, bioavailability, metabolism and excretion of δ-viniferin in rats
por: Mao, Ping, et al.
Publicado: (2016)

The Absorption, Distribution and Excretion of (3)H-Chlorambucil in Rats Bearing the Yoshida Ascites Sarcoma
por: Hill, Bridget T., et al.
Publicado: (1971)

Pharmacokinetics, Tissue Distribution, Excretion and Plasma Protein Binding Studies of Wogonin in Rats
por: Talbi, Amer, et al.
Publicado: (2014)

Pharmacokinetics, Tissue Distribution and Excretion of a Novel Diuretic (PU-48) in Rats
por: Zhang, Zhi-Yuan, et al.
Publicado: (2018)

Absorption and Excretion of Antipyrine
Publicado: (1888)

Absorption, distribution, metabolism, and excretion of [(14)C]-labeled naloxegol in healthy subjects
por: Bui, Khanh, et al.
Publicado: (2015)

Polymorphisms in genes involved in the absorption, distribution, metabolism, and excretion of drugs in the Kazakhs of Kazakhstan
por: Iskakova, Aisha N., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_luag1jlprd25hcf9infvon61r8