A review of current evidence about lncRNA MEG3: A tumor suppressor in multiple cancers

Long non-coding RNA (lncRNA) maternally expressed gene 3 (MEG3) is a lncRNA located at the DLK1-MEG3 site of human chromosome 14q32.3. The expression of MEG3 in various tumors is substantially lower than that in normal adjacent tissues, and deletion of MEG3 expression is involved in the occurrence o...

Descripción completa

Detalles Bibliográficos
Autores principales: Xu, Jie, Wang, Xia, Zhu, Chunming, Wang, Kefeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9760833/
https://www.ncbi.nlm.nih.gov/pubmed/36544907
http://dx.doi.org/10.3389/fcell.2022.997633
_version_ 1784852569040879616
author Xu, Jie
Wang, Xia
Zhu, Chunming
Wang, Kefeng
author_facet Xu, Jie
Wang, Xia
Zhu, Chunming
Wang, Kefeng
author_sort Xu, Jie
collection PubMed
description Long non-coding RNA (lncRNA) maternally expressed gene 3 (MEG3) is a lncRNA located at the DLK1-MEG3 site of human chromosome 14q32.3. The expression of MEG3 in various tumors is substantially lower than that in normal adjacent tissues, and deletion of MEG3 expression is involved in the occurrence of many tumors. The high expression of MEG3 could inhibit the occurrence and development of tumors through several mechanisms, which has become a research hotspot in recent years. As a member of tumor suppressor lncRNAs, MEG3 is expected to be a new target for tumor diagnosis and treatment. This review discusses the molecular mechanisms of MEG3 in different tumors and future challenges for the diagnosis and treatment of cancers through MEG3.
format Online
Article
Text
id pubmed-9760833
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-97608332022-12-20 A review of current evidence about lncRNA MEG3: A tumor suppressor in multiple cancers Xu, Jie Wang, Xia Zhu, Chunming Wang, Kefeng Front Cell Dev Biol Cell and Developmental Biology Long non-coding RNA (lncRNA) maternally expressed gene 3 (MEG3) is a lncRNA located at the DLK1-MEG3 site of human chromosome 14q32.3. The expression of MEG3 in various tumors is substantially lower than that in normal adjacent tissues, and deletion of MEG3 expression is involved in the occurrence of many tumors. The high expression of MEG3 could inhibit the occurrence and development of tumors through several mechanisms, which has become a research hotspot in recent years. As a member of tumor suppressor lncRNAs, MEG3 is expected to be a new target for tumor diagnosis and treatment. This review discusses the molecular mechanisms of MEG3 in different tumors and future challenges for the diagnosis and treatment of cancers through MEG3. Frontiers Media S.A. 2022-12-05 /pmc/articles/PMC9760833/ /pubmed/36544907 http://dx.doi.org/10.3389/fcell.2022.997633 Text en Copyright © 2022 Xu, Wang, Zhu and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Xu, Jie
Wang, Xia
Zhu, Chunming
Wang, Kefeng
A review of current evidence about lncRNA MEG3: A tumor suppressor in multiple cancers
title A review of current evidence about lncRNA MEG3: A tumor suppressor in multiple cancers
title_full A review of current evidence about lncRNA MEG3: A tumor suppressor in multiple cancers
title_fullStr A review of current evidence about lncRNA MEG3: A tumor suppressor in multiple cancers
title_full_unstemmed A review of current evidence about lncRNA MEG3: A tumor suppressor in multiple cancers
title_short A review of current evidence about lncRNA MEG3: A tumor suppressor in multiple cancers
title_sort review of current evidence about lncrna meg3: a tumor suppressor in multiple cancers
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9760833/
https://www.ncbi.nlm.nih.gov/pubmed/36544907
http://dx.doi.org/10.3389/fcell.2022.997633
work_keys_str_mv AT xujie areviewofcurrentevidenceaboutlncrnameg3atumorsuppressorinmultiplecancers
AT wangxia areviewofcurrentevidenceaboutlncrnameg3atumorsuppressorinmultiplecancers
AT zhuchunming areviewofcurrentevidenceaboutlncrnameg3atumorsuppressorinmultiplecancers
AT wangkefeng areviewofcurrentevidenceaboutlncrnameg3atumorsuppressorinmultiplecancers
AT xujie reviewofcurrentevidenceaboutlncrnameg3atumorsuppressorinmultiplecancers
AT wangxia reviewofcurrentevidenceaboutlncrnameg3atumorsuppressorinmultiplecancers
AT zhuchunming reviewofcurrentevidenceaboutlncrnameg3atumorsuppressorinmultiplecancers
AT wangkefeng reviewofcurrentevidenceaboutlncrnameg3atumorsuppressorinmultiplecancers

Ejemplares similares