IgE-expressing long-lived plasma cells in persistent sensitization

Persistent allergies affect the quality of life of patients and increase economic burdens. Many clinical observations indicate the presence of IgE(+) long-lived plasma cells (LLPCs), which account for the persistent secretion of specific IgE; however, the characteristics of the IgE(+) LLPCs have yet...

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Detalles Bibliográficos
Autores principales: Xiong, Shiqiu, Jia, Yang, Liu, Chuanhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pediatrics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9760851/
https://www.ncbi.nlm.nih.gov/pubmed/36545659
http://dx.doi.org/10.3389/fped.2022.979012
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author Xiong, Shiqiu
Jia, Yang
Liu, Chuanhe
author_facet Xiong, Shiqiu
Jia, Yang
Liu, Chuanhe
author_sort Xiong, Shiqiu
collection PubMed
description Persistent allergies affect the quality of life of patients and increase economic burdens. Many clinical observations indicate the presence of IgE(+) long-lived plasma cells (LLPCs), which account for the persistent secretion of specific IgE; however, the characteristics of the IgE(+) LLPCs have yet to be identified clearly. In this review, we summarized the generation of IgE(+) PCs, discussed the prosurvival factors in the microenvironment, and reviewed the unique IgE-BCR signaling, which may bring insights into understanding the survival mechanisms of IgE(+) LLPCs.
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spelling pubmed-97608512022-12-20 IgE-expressing long-lived plasma cells in persistent sensitization Xiong, Shiqiu Jia, Yang Liu, Chuanhe Front Pediatr Pediatrics Persistent allergies affect the quality of life of patients and increase economic burdens. Many clinical observations indicate the presence of IgE(+) long-lived plasma cells (LLPCs), which account for the persistent secretion of specific IgE; however, the characteristics of the IgE(+) LLPCs have yet to be identified clearly. In this review, we summarized the generation of IgE(+) PCs, discussed the prosurvival factors in the microenvironment, and reviewed the unique IgE-BCR signaling, which may bring insights into understanding the survival mechanisms of IgE(+) LLPCs. Frontiers Media S.A. 2022-12-05 /pmc/articles/PMC9760851/ /pubmed/36545659 http://dx.doi.org/10.3389/fped.2022.979012 Text en © 2022 Xiong, Jia and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Xiong, Shiqiu
Jia, Yang
Liu, Chuanhe
IgE-expressing long-lived plasma cells in persistent sensitization
title IgE-expressing long-lived plasma cells in persistent sensitization
title_full IgE-expressing long-lived plasma cells in persistent sensitization
title_fullStr IgE-expressing long-lived plasma cells in persistent sensitization
title_full_unstemmed IgE-expressing long-lived plasma cells in persistent sensitization
title_short IgE-expressing long-lived plasma cells in persistent sensitization
title_sort ige-expressing long-lived plasma cells in persistent sensitization
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9760851/
https://www.ncbi.nlm.nih.gov/pubmed/36545659
http://dx.doi.org/10.3389/fped.2022.979012
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