Cargando…

Transcutaneous electrical acupoint stimulation for reducing cognitive dysfunction in lumbar spine surgery: A randomized, controlled trail

OBJECTIVE: This study aimed to evaluate the effect of perioperative transcutaneous electrical acupoint stimulation (TEAS) on postoperative cognitive dysfunction (POCD) in older patients with lumbar spine surgery. METHODS: Older patients (aged 60–80 years old) receiving lumbar spine surgery under gen...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Li-feng, Liang, Wei-dong, Wang, Bing-yu, Guo, Ming-ling, Zhou, Jian-shun, Chen, Li, Zhong, Mao-lin, Ye, Jun-ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9760873/
https://www.ncbi.nlm.nih.gov/pubmed/36545028
http://dx.doi.org/10.3389/fnagi.2022.1034998
_version_ 1784852578876522496
author Wang, Li-feng
Liang, Wei-dong
Wang, Bing-yu
Guo, Ming-ling
Zhou, Jian-shun
Chen, Li
Zhong, Mao-lin
Ye, Jun-ming
author_facet Wang, Li-feng
Liang, Wei-dong
Wang, Bing-yu
Guo, Ming-ling
Zhou, Jian-shun
Chen, Li
Zhong, Mao-lin
Ye, Jun-ming
author_sort Wang, Li-feng
collection PubMed
description OBJECTIVE: This study aimed to evaluate the effect of perioperative transcutaneous electrical acupoint stimulation (TEAS) on postoperative cognitive dysfunction (POCD) in older patients with lumbar spine surgery. METHODS: Older patients (aged 60–80 years old) receiving lumbar spine surgery under general anesthesia were randomly divided into group A, 3-day intervention group; group B, 7-day intervention group; control group C, sham TEAS group, selected “Baihui” (GV 20) and “Dazhui” (GV 14) point was intervened once 30 min before operation with “HANS” transcutaneous electrical stimulation device, and then once a day after operation for 30 min each time. The primary outcome was the incidence of postoperative cognitive impairment assessed by the use of the Mini Mental Rating Scale (MMSE), patients developed POCD according to the Z score method. The secondary outcome was serum interleukin-6 (IL-6), tumor Necrosis factor α (TNF-α), neuron-specific enolase (NSE), and S100β protein levels. RESULTS: Three days after surgery, the incidence of POCD in groups A((22.4%)) and B ((18.3%)) were lower than those in group C ((42.9%)) (P < 0.05). There was no significant difference between groups A and B (P > 0.05). Seven days after surgery, the incidence of POCD in group B (18.3%) was lower than that in groups A (26.5%) and B (42.9%), and the comparison between groups B and C was statistically significant (P < 0.05). On the 3rd and 7th days after surgery, the levels of IL-6, TNF-α, NSE, and S100β in the two TEAS groups were lower than those in the sham TEAS group (P < 0.01), but higher than the preoperative levels in the three groups (P < 0.01). CONCLUSION: It seems that Perioperative TEAS intervention could reduce the level of inflammatory factors IL-6, TNF-α in the blood of older patients with lumbar spine surgery, and reduce the incidence of POCD. CLINICAL TRIAL REGISTRATION: www.chictr.org.cn, identifier ChiCTR2200063030.
format Online
Article
Text
id pubmed-9760873
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-97608732022-12-20 Transcutaneous electrical acupoint stimulation for reducing cognitive dysfunction in lumbar spine surgery: A randomized, controlled trail Wang, Li-feng Liang, Wei-dong Wang, Bing-yu Guo, Ming-ling Zhou, Jian-shun Chen, Li Zhong, Mao-lin Ye, Jun-ming Front Aging Neurosci Neuroscience OBJECTIVE: This study aimed to evaluate the effect of perioperative transcutaneous electrical acupoint stimulation (TEAS) on postoperative cognitive dysfunction (POCD) in older patients with lumbar spine surgery. METHODS: Older patients (aged 60–80 years old) receiving lumbar spine surgery under general anesthesia were randomly divided into group A, 3-day intervention group; group B, 7-day intervention group; control group C, sham TEAS group, selected “Baihui” (GV 20) and “Dazhui” (GV 14) point was intervened once 30 min before operation with “HANS” transcutaneous electrical stimulation device, and then once a day after operation for 30 min each time. The primary outcome was the incidence of postoperative cognitive impairment assessed by the use of the Mini Mental Rating Scale (MMSE), patients developed POCD according to the Z score method. The secondary outcome was serum interleukin-6 (IL-6), tumor Necrosis factor α (TNF-α), neuron-specific enolase (NSE), and S100β protein levels. RESULTS: Three days after surgery, the incidence of POCD in groups A((22.4%)) and B ((18.3%)) were lower than those in group C ((42.9%)) (P < 0.05). There was no significant difference between groups A and B (P > 0.05). Seven days after surgery, the incidence of POCD in group B (18.3%) was lower than that in groups A (26.5%) and B (42.9%), and the comparison between groups B and C was statistically significant (P < 0.05). On the 3rd and 7th days after surgery, the levels of IL-6, TNF-α, NSE, and S100β in the two TEAS groups were lower than those in the sham TEAS group (P < 0.01), but higher than the preoperative levels in the three groups (P < 0.01). CONCLUSION: It seems that Perioperative TEAS intervention could reduce the level of inflammatory factors IL-6, TNF-α in the blood of older patients with lumbar spine surgery, and reduce the incidence of POCD. CLINICAL TRIAL REGISTRATION: www.chictr.org.cn, identifier ChiCTR2200063030. Frontiers Media S.A. 2022-12-05 /pmc/articles/PMC9760873/ /pubmed/36545028 http://dx.doi.org/10.3389/fnagi.2022.1034998 Text en Copyright © 2022 Wang, Liang, Wang, Guo, Zhou, Chen, Zhong and Ye. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Wang, Li-feng
Liang, Wei-dong
Wang, Bing-yu
Guo, Ming-ling
Zhou, Jian-shun
Chen, Li
Zhong, Mao-lin
Ye, Jun-ming
Transcutaneous electrical acupoint stimulation for reducing cognitive dysfunction in lumbar spine surgery: A randomized, controlled trail
title Transcutaneous electrical acupoint stimulation for reducing cognitive dysfunction in lumbar spine surgery: A randomized, controlled trail
title_full Transcutaneous electrical acupoint stimulation for reducing cognitive dysfunction in lumbar spine surgery: A randomized, controlled trail
title_fullStr Transcutaneous electrical acupoint stimulation for reducing cognitive dysfunction in lumbar spine surgery: A randomized, controlled trail
title_full_unstemmed Transcutaneous electrical acupoint stimulation for reducing cognitive dysfunction in lumbar spine surgery: A randomized, controlled trail
title_short Transcutaneous electrical acupoint stimulation for reducing cognitive dysfunction in lumbar spine surgery: A randomized, controlled trail
title_sort transcutaneous electrical acupoint stimulation for reducing cognitive dysfunction in lumbar spine surgery: a randomized, controlled trail
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9760873/
https://www.ncbi.nlm.nih.gov/pubmed/36545028
http://dx.doi.org/10.3389/fnagi.2022.1034998
work_keys_str_mv AT wanglifeng transcutaneouselectricalacupointstimulationforreducingcognitivedysfunctioninlumbarspinesurgeryarandomizedcontrolledtrail
AT liangweidong transcutaneouselectricalacupointstimulationforreducingcognitivedysfunctioninlumbarspinesurgeryarandomizedcontrolledtrail
AT wangbingyu transcutaneouselectricalacupointstimulationforreducingcognitivedysfunctioninlumbarspinesurgeryarandomizedcontrolledtrail
AT guomingling transcutaneouselectricalacupointstimulationforreducingcognitivedysfunctioninlumbarspinesurgeryarandomizedcontrolledtrail
AT zhoujianshun transcutaneouselectricalacupointstimulationforreducingcognitivedysfunctioninlumbarspinesurgeryarandomizedcontrolledtrail
AT chenli transcutaneouselectricalacupointstimulationforreducingcognitivedysfunctioninlumbarspinesurgeryarandomizedcontrolledtrail
AT zhongmaolin transcutaneouselectricalacupointstimulationforreducingcognitivedysfunctioninlumbarspinesurgeryarandomizedcontrolledtrail
AT yejunming transcutaneouselectricalacupointstimulationforreducingcognitivedysfunctioninlumbarspinesurgeryarandomizedcontrolledtrail