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Underlying beneficial effects of Rhubarb on constipation-induced inflammation, disorder of gut microbiome and metabolism

Background: Constipation is a common syndrome and a worldwide healthy problem. Constipation patients are becoming younger, with a 29.6% overall prevalence in children, which has captured significant attention because of its epigenetic rejuvenation and recurrent episodes. Despite the usage of rhubarb...

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Autores principales: Gao, Han, He, Chengwei, Hua, Rongxuan, Liang, Chen, Wang, Boya, Du, Yixuan, Xin, Shuzi, Guo, Yuexin, Gao, Lei, Zhang, Lucia, Shang, Hongwei, Xu, Jingdong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9760883/
https://www.ncbi.nlm.nih.gov/pubmed/36545319
http://dx.doi.org/10.3389/fphar.2022.1048134
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author Gao, Han
He, Chengwei
Hua, Rongxuan
Liang, Chen
Wang, Boya
Du, Yixuan
Xin, Shuzi
Guo, Yuexin
Gao, Lei
Zhang, Lucia
Shang, Hongwei
Xu, Jingdong
author_facet Gao, Han
He, Chengwei
Hua, Rongxuan
Liang, Chen
Wang, Boya
Du, Yixuan
Xin, Shuzi
Guo, Yuexin
Gao, Lei
Zhang, Lucia
Shang, Hongwei
Xu, Jingdong
author_sort Gao, Han
collection PubMed
description Background: Constipation is a common syndrome and a worldwide healthy problem. Constipation patients are becoming younger, with a 29.6% overall prevalence in children, which has captured significant attention because of its epigenetic rejuvenation and recurrent episodes. Despite the usage of rhubarb extract to relieve constipation, novel targets and genes implicated in target-relevant pathways with remarkable functionalities should still be sought for. Materials and methods: We established a reliable constipation model in C57B/6N male mice using intragastric administration diphenoxylate, and the eligible subjects received 600 mg/25 g rhubarb extract to alleviate constipation. Resultant constipation was morphological and genetically compared with the specimen from different groups. Results: Constipation mice exhibited thicker muscle layers, higher levels of cytokines, including IL-17 and IL-23, and lower content of IL-22. Bacterial abundance and diversity varied tremendously. Notably, the alterations were reversed following rhubarb extract treatment. Additionally, Constipation also had a substantial impact on short-chain fatty acids (SCFAs), medium- and long-chain fatty acids (MLCFAs), and the expression of SCFA receptors, GPR41 and GPR43. Conclusion: This thesis has provided insight that rhubarb extract promoted the flexibility of collagen fiber, reduced pro-inflammatory cytokines, enhanced anti-inflammatory cytokines, and maintained gut microflora balance with potential impacts on the fatty acid and polyamine metabolism.
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spelling pubmed-97608832022-12-20 Underlying beneficial effects of Rhubarb on constipation-induced inflammation, disorder of gut microbiome and metabolism Gao, Han He, Chengwei Hua, Rongxuan Liang, Chen Wang, Boya Du, Yixuan Xin, Shuzi Guo, Yuexin Gao, Lei Zhang, Lucia Shang, Hongwei Xu, Jingdong Front Pharmacol Pharmacology Background: Constipation is a common syndrome and a worldwide healthy problem. Constipation patients are becoming younger, with a 29.6% overall prevalence in children, which has captured significant attention because of its epigenetic rejuvenation and recurrent episodes. Despite the usage of rhubarb extract to relieve constipation, novel targets and genes implicated in target-relevant pathways with remarkable functionalities should still be sought for. Materials and methods: We established a reliable constipation model in C57B/6N male mice using intragastric administration diphenoxylate, and the eligible subjects received 600 mg/25 g rhubarb extract to alleviate constipation. Resultant constipation was morphological and genetically compared with the specimen from different groups. Results: Constipation mice exhibited thicker muscle layers, higher levels of cytokines, including IL-17 and IL-23, and lower content of IL-22. Bacterial abundance and diversity varied tremendously. Notably, the alterations were reversed following rhubarb extract treatment. Additionally, Constipation also had a substantial impact on short-chain fatty acids (SCFAs), medium- and long-chain fatty acids (MLCFAs), and the expression of SCFA receptors, GPR41 and GPR43. Conclusion: This thesis has provided insight that rhubarb extract promoted the flexibility of collagen fiber, reduced pro-inflammatory cytokines, enhanced anti-inflammatory cytokines, and maintained gut microflora balance with potential impacts on the fatty acid and polyamine metabolism. Frontiers Media S.A. 2022-12-05 /pmc/articles/PMC9760883/ /pubmed/36545319 http://dx.doi.org/10.3389/fphar.2022.1048134 Text en Copyright © 2022 Gao, He, Hua, Liang, Wang, Du, Xin, Guo, Gao, Zhang, Shang and Xu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Gao, Han
He, Chengwei
Hua, Rongxuan
Liang, Chen
Wang, Boya
Du, Yixuan
Xin, Shuzi
Guo, Yuexin
Gao, Lei
Zhang, Lucia
Shang, Hongwei
Xu, Jingdong
Underlying beneficial effects of Rhubarb on constipation-induced inflammation, disorder of gut microbiome and metabolism
title Underlying beneficial effects of Rhubarb on constipation-induced inflammation, disorder of gut microbiome and metabolism
title_full Underlying beneficial effects of Rhubarb on constipation-induced inflammation, disorder of gut microbiome and metabolism
title_fullStr Underlying beneficial effects of Rhubarb on constipation-induced inflammation, disorder of gut microbiome and metabolism
title_full_unstemmed Underlying beneficial effects of Rhubarb on constipation-induced inflammation, disorder of gut microbiome and metabolism
title_short Underlying beneficial effects of Rhubarb on constipation-induced inflammation, disorder of gut microbiome and metabolism
title_sort underlying beneficial effects of rhubarb on constipation-induced inflammation, disorder of gut microbiome and metabolism
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9760883/
https://www.ncbi.nlm.nih.gov/pubmed/36545319
http://dx.doi.org/10.3389/fphar.2022.1048134
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