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EMILIN2 is associated with prognosis and immunotherapy in clear cell renal cell carcinoma
Background: EMILIN2 is a platelet-associated elastin that regulates angiogenesis. It has recently been found to play an essential role in various tumors. Nevertheless, the mechanism of action of EMILIN2 in clear cell renal cell carcinoma (ccRCC) remains unclear. Methods: Samples from 33 cancers were...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9760906/ https://www.ncbi.nlm.nih.gov/pubmed/36544490 http://dx.doi.org/10.3389/fgene.2022.1058207 |
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author | Zhao, Guangjian Zheng, Jianpei Tang, Kai Chen, Qi |
author_facet | Zhao, Guangjian Zheng, Jianpei Tang, Kai Chen, Qi |
author_sort | Zhao, Guangjian |
collection | PubMed |
description | Background: EMILIN2 is a platelet-associated elastin that regulates angiogenesis. It has recently been found to play an essential role in various tumors. Nevertheless, the mechanism of action of EMILIN2 in clear cell renal cell carcinoma (ccRCC) remains unclear. Methods: Samples from 33 cancers were obtained from UCSC Xena and The Cancer Genome Atlas (TCGA) database. The relationship between EMILIN2 expression and the clinicopathological characteristics and immune infiltration of ccRCC was investigated. Nonnegative matrix factorization (NMF) was used to classify ccRCC patients. A multigene risk prediction model of ccRCC was constructed using LASSO regression and multivariate regression analysis. A nomogram survival probability prediction map and calibration curve were constructed based on clinical information. Results: EMILIN2 is significantly overexpressed in ccRCC, a phenomenon that is associated with poor prognosis. Meanwhile, EMILIN2 expression is closely related to tumor immune infiltration in ccRCC. Patients with clear cell renal cell carcinoma were divided into two subtypes using NMF, with subtype 2 showed poor prognosis. Next, we established a risk score model for ccRCC based on the common differentially expressed genes (DEGs) between subtypes and groups based on EMILIN2 expression. The results indicated poor prognosis in the high-risk group in the training set and were confirmed in the validation set. Conclusion: Our findings suggest that EMILIN2 expression is closely associated with immune infiltration in ccRCC. EMILIN2 expression is negatively correlated with the prognosis of ccRCC patients. Here, we developed a tool that could predict the prognosis of ccRCC patients. |
format | Online Article Text |
id | pubmed-9760906 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97609062022-12-20 EMILIN2 is associated with prognosis and immunotherapy in clear cell renal cell carcinoma Zhao, Guangjian Zheng, Jianpei Tang, Kai Chen, Qi Front Genet Genetics Background: EMILIN2 is a platelet-associated elastin that regulates angiogenesis. It has recently been found to play an essential role in various tumors. Nevertheless, the mechanism of action of EMILIN2 in clear cell renal cell carcinoma (ccRCC) remains unclear. Methods: Samples from 33 cancers were obtained from UCSC Xena and The Cancer Genome Atlas (TCGA) database. The relationship between EMILIN2 expression and the clinicopathological characteristics and immune infiltration of ccRCC was investigated. Nonnegative matrix factorization (NMF) was used to classify ccRCC patients. A multigene risk prediction model of ccRCC was constructed using LASSO regression and multivariate regression analysis. A nomogram survival probability prediction map and calibration curve were constructed based on clinical information. Results: EMILIN2 is significantly overexpressed in ccRCC, a phenomenon that is associated with poor prognosis. Meanwhile, EMILIN2 expression is closely related to tumor immune infiltration in ccRCC. Patients with clear cell renal cell carcinoma were divided into two subtypes using NMF, with subtype 2 showed poor prognosis. Next, we established a risk score model for ccRCC based on the common differentially expressed genes (DEGs) between subtypes and groups based on EMILIN2 expression. The results indicated poor prognosis in the high-risk group in the training set and were confirmed in the validation set. Conclusion: Our findings suggest that EMILIN2 expression is closely associated with immune infiltration in ccRCC. EMILIN2 expression is negatively correlated with the prognosis of ccRCC patients. Here, we developed a tool that could predict the prognosis of ccRCC patients. Frontiers Media S.A. 2022-12-05 /pmc/articles/PMC9760906/ /pubmed/36544490 http://dx.doi.org/10.3389/fgene.2022.1058207 Text en Copyright © 2022 Zhao, Zheng, Tang and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Genetics Zhao, Guangjian Zheng, Jianpei Tang, Kai Chen, Qi EMILIN2 is associated with prognosis and immunotherapy in clear cell renal cell carcinoma |
title | EMILIN2 is associated with prognosis and immunotherapy in clear cell renal cell carcinoma |
title_full | EMILIN2 is associated with prognosis and immunotherapy in clear cell renal cell carcinoma |
title_fullStr | EMILIN2 is associated with prognosis and immunotherapy in clear cell renal cell carcinoma |
title_full_unstemmed | EMILIN2 is associated with prognosis and immunotherapy in clear cell renal cell carcinoma |
title_short | EMILIN2 is associated with prognosis and immunotherapy in clear cell renal cell carcinoma |
title_sort | emilin2 is associated with prognosis and immunotherapy in clear cell renal cell carcinoma |
topic | Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9760906/ https://www.ncbi.nlm.nih.gov/pubmed/36544490 http://dx.doi.org/10.3389/fgene.2022.1058207 |
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