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Moderate exercise protects against joint disease in a murine model of osteoarthritis

Exercise is recommended as a non-pharmacological therapy for osteoarthritis (OA). Various exercise regimes, with differing intensities and duration, have been used in a range of OA rodent models. These studies show gentle or moderate exercise reduces the severity of OA parameters while high intensit...

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Autores principales: Huesa, C., Dunning, L., MacDougall, K., Fegen, M., Ortiz, A., McCulloch, K., McGrath, S., Litherland, G. J., Crilly, A., Van ‘T Hof, R. J., Ferrell, W. R., Goodyear, C. S., Lockhart, J. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9760924/
https://www.ncbi.nlm.nih.gov/pubmed/36545287
http://dx.doi.org/10.3389/fphys.2022.1065278
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author Huesa, C.
Dunning, L.
MacDougall, K.
Fegen, M.
Ortiz, A.
McCulloch, K.
McGrath, S.
Litherland, G. J.
Crilly, A.
Van ‘T Hof, R. J.
Ferrell, W. R.
Goodyear, C. S.
Lockhart, J. C.
author_facet Huesa, C.
Dunning, L.
MacDougall, K.
Fegen, M.
Ortiz, A.
McCulloch, K.
McGrath, S.
Litherland, G. J.
Crilly, A.
Van ‘T Hof, R. J.
Ferrell, W. R.
Goodyear, C. S.
Lockhart, J. C.
author_sort Huesa, C.
collection PubMed
description Exercise is recommended as a non-pharmacological therapy for osteoarthritis (OA). Various exercise regimes, with differing intensities and duration, have been used in a range of OA rodent models. These studies show gentle or moderate exercise reduces the severity of OA parameters while high intensity load bearing exercise is detrimental. However, these studies were largely conducted in rats or in mouse models induced by severe injury, age or obesity, whilst destabilization of the medial meniscus (DMM) in mice has become a widely accepted model due to its lower variability, moderate progression and timescale. The present study was undertaken to provide insight into the effect of moderate exercise on early joint pathology in the DMM mouse model. Exercise was induced a week after induction by forced wheel walking for three or 7 weeks. Joints were analyzed by microcomputed tomography and histology. Assessment of skeletal parameters revealed that exercise offered protection against cartilage damage after 7 weeks of exercise, and a temporary protection against osteosclerosis was displayed after 3 weeks of exercise. Furthermore, exercise modified the metaphyseal trabecular microarchitecture of the osteoarthritic leg in both time points examined. Collectively, our findings corroborate previous studies showing that exercise has an important effect on bone in OA, which subsequently, at 8 weeks post-induction, translates into less cartilage damage. Thus, providing an exercise protocol in a surgical mouse model of OA, which can be used in the future to further dissect the mechanisms by which moderate exercise ameliorates OA.
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spelling pubmed-97609242022-12-20 Moderate exercise protects against joint disease in a murine model of osteoarthritis Huesa, C. Dunning, L. MacDougall, K. Fegen, M. Ortiz, A. McCulloch, K. McGrath, S. Litherland, G. J. Crilly, A. Van ‘T Hof, R. J. Ferrell, W. R. Goodyear, C. S. Lockhart, J. C. Front Physiol Physiology Exercise is recommended as a non-pharmacological therapy for osteoarthritis (OA). Various exercise regimes, with differing intensities and duration, have been used in a range of OA rodent models. These studies show gentle or moderate exercise reduces the severity of OA parameters while high intensity load bearing exercise is detrimental. However, these studies were largely conducted in rats or in mouse models induced by severe injury, age or obesity, whilst destabilization of the medial meniscus (DMM) in mice has become a widely accepted model due to its lower variability, moderate progression and timescale. The present study was undertaken to provide insight into the effect of moderate exercise on early joint pathology in the DMM mouse model. Exercise was induced a week after induction by forced wheel walking for three or 7 weeks. Joints were analyzed by microcomputed tomography and histology. Assessment of skeletal parameters revealed that exercise offered protection against cartilage damage after 7 weeks of exercise, and a temporary protection against osteosclerosis was displayed after 3 weeks of exercise. Furthermore, exercise modified the metaphyseal trabecular microarchitecture of the osteoarthritic leg in both time points examined. Collectively, our findings corroborate previous studies showing that exercise has an important effect on bone in OA, which subsequently, at 8 weeks post-induction, translates into less cartilage damage. Thus, providing an exercise protocol in a surgical mouse model of OA, which can be used in the future to further dissect the mechanisms by which moderate exercise ameliorates OA. Frontiers Media S.A. 2022-12-05 /pmc/articles/PMC9760924/ /pubmed/36545287 http://dx.doi.org/10.3389/fphys.2022.1065278 Text en Copyright © 2022 Huesa, Dunning, MacDougall, Fegen, Ortiz, McCulloch, McGrath, Litherland, Crilly, Van ‘T Hof, Ferrell, Goodyear and Lockhart. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Huesa, C.
Dunning, L.
MacDougall, K.
Fegen, M.
Ortiz, A.
McCulloch, K.
McGrath, S.
Litherland, G. J.
Crilly, A.
Van ‘T Hof, R. J.
Ferrell, W. R.
Goodyear, C. S.
Lockhart, J. C.
Moderate exercise protects against joint disease in a murine model of osteoarthritis
title Moderate exercise protects against joint disease in a murine model of osteoarthritis
title_full Moderate exercise protects against joint disease in a murine model of osteoarthritis
title_fullStr Moderate exercise protects against joint disease in a murine model of osteoarthritis
title_full_unstemmed Moderate exercise protects against joint disease in a murine model of osteoarthritis
title_short Moderate exercise protects against joint disease in a murine model of osteoarthritis
title_sort moderate exercise protects against joint disease in a murine model of osteoarthritis
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9760924/
https://www.ncbi.nlm.nih.gov/pubmed/36545287
http://dx.doi.org/10.3389/fphys.2022.1065278
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