Plasma cell free next-generation sequencing detects an unusual pneumonia pathogen in an immunocompetent adolescent with acute respiratory distress syndrome

This case details a rapid diagnosis of legionella pneumonia causing severe acute respiratory distress syndrome (ARDS) in an otherwise healthy adolescent through plasma microbial cell-free DNA next generation sequencing (mcfDNA-NGS). Diagnosis by mcfDNA-NGS of this unexpected pathogen led to narrowin...

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Autores principales: Rodriguez, Katherine M., Ramchandar, Nanda, Coufal, Nicole G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pediatrics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9760936/
https://www.ncbi.nlm.nih.gov/pubmed/36545658
http://dx.doi.org/10.3389/fped.2022.1034632
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author Rodriguez, Katherine M.
Ramchandar, Nanda
Coufal, Nicole G.
author_facet Rodriguez, Katherine M.
Ramchandar, Nanda
Coufal, Nicole G.
author_sort Rodriguez, Katherine M.
collection PubMed
description This case details a rapid diagnosis of legionella pneumonia causing severe acute respiratory distress syndrome (ARDS) in an otherwise healthy adolescent through plasma microbial cell-free DNA next generation sequencing (mcfDNA-NGS). Diagnosis by mcfDNA-NGS of this unexpected pathogen led to narrowing of antimicrobials and the addition of glucocorticoids as adjunctive therapy for ARDS.
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spelling pubmed-97609362022-12-20 Plasma cell free next-generation sequencing detects an unusual pneumonia pathogen in an immunocompetent adolescent with acute respiratory distress syndrome Rodriguez, Katherine M. Ramchandar, Nanda Coufal, Nicole G. Front Pediatr Pediatrics This case details a rapid diagnosis of legionella pneumonia causing severe acute respiratory distress syndrome (ARDS) in an otherwise healthy adolescent through plasma microbial cell-free DNA next generation sequencing (mcfDNA-NGS). Diagnosis by mcfDNA-NGS of this unexpected pathogen led to narrowing of antimicrobials and the addition of glucocorticoids as adjunctive therapy for ARDS. Frontiers Media S.A. 2022-12-05 /pmc/articles/PMC9760936/ /pubmed/36545658 http://dx.doi.org/10.3389/fped.2022.1034632 Text en © 2022 Rodriguez, Ramchandar and Coufal. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Rodriguez, Katherine M.
Ramchandar, Nanda
Coufal, Nicole G.
Plasma cell free next-generation sequencing detects an unusual pneumonia pathogen in an immunocompetent adolescent with acute respiratory distress syndrome
title Plasma cell free next-generation sequencing detects an unusual pneumonia pathogen in an immunocompetent adolescent with acute respiratory distress syndrome
title_full Plasma cell free next-generation sequencing detects an unusual pneumonia pathogen in an immunocompetent adolescent with acute respiratory distress syndrome
title_fullStr Plasma cell free next-generation sequencing detects an unusual pneumonia pathogen in an immunocompetent adolescent with acute respiratory distress syndrome
title_full_unstemmed Plasma cell free next-generation sequencing detects an unusual pneumonia pathogen in an immunocompetent adolescent with acute respiratory distress syndrome
title_short Plasma cell free next-generation sequencing detects an unusual pneumonia pathogen in an immunocompetent adolescent with acute respiratory distress syndrome
title_sort plasma cell free next-generation sequencing detects an unusual pneumonia pathogen in an immunocompetent adolescent with acute respiratory distress syndrome
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9760936/
https://www.ncbi.nlm.nih.gov/pubmed/36545658
http://dx.doi.org/10.3389/fped.2022.1034632
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AT coufalnicoleg plasmacellfreenextgenerationsequencingdetectsanunusualpneumoniapathogeninanimmunocompetentadolescentwithacuterespiratorydistresssyndrome

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