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Risk factors for early mortality of lung cancer patients in France: A nationwide analysis
BACKGROUND: Despite therapeutic advances, lung cancer remains the first cause of death from cancer. The main objective of this study was to identify risk factors associated with death within 3‐months of the first hospitalization for lung cancer in France. METHODS: This analysis included patients wit...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9761075/ https://www.ncbi.nlm.nih.gov/pubmed/35567378 http://dx.doi.org/10.1002/cam4.4821 |
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author | Goussault, Hélène Gendarme, Sébastien Assié, Jean‐Baptiste Jung, Camille Epaud, Salomé Algans, Christelle Salaun‐Penquer, Noémie Rousseau, Mathilde Lazatti, Andrea Chouaïd, Christos |
author_facet | Goussault, Hélène Gendarme, Sébastien Assié, Jean‐Baptiste Jung, Camille Epaud, Salomé Algans, Christelle Salaun‐Penquer, Noémie Rousseau, Mathilde Lazatti, Andrea Chouaïd, Christos |
author_sort | Goussault, Hélène |
collection | PubMed |
description | BACKGROUND: Despite therapeutic advances, lung cancer remains the first cause of death from cancer. The main objective of this study was to identify risk factors associated with death within 3‐months of the first hospitalization for lung cancer in France. METHODS: This analysis included patients with a first hospitalization for lung cancer (between January 1, 2016 and December 31, 2018) according to diagnosis‐related groups entered into the French national medical‐administrative database. Clinical and socioeconomic parameters and characteristics of that first hospitalization were analyzed. A model predictive of early mortality was developed based on those variables. RESULTS: The 144,087 included patients were 67% men; median age of 68 [interquartile range 60–76] years; 47% had metastatic disease at diagnosis; and 34% and 23%, respectively, had received systemic treatment or undergone curative surgery. The 3‐month mortality was 19%, and significantly higher for those ≥70 versus <70 years old (OR 1.33, 1.22–1.45), men versus. women (OR 1.50, 1.44–1.55), those with metastatic disease at diagnosis (OR, 3.30, 3.18–3.43), first hospitalization via the emergency room (OR 1.65 1.59–1.71) and first hospitalization lasting >30 days (OR, 1.58 1.49–1.68). In contrast, no socioeconomic characteristic was associated with early mortality. CONCLUSION: Almost 1 in 5 patients diagnosed with lung cancer in France died within 3 months post‐diagnosis. Improving survival requires diagnosis at an earlier stage and better organization of diagnosis and specific care pathways. |
format | Online Article Text |
id | pubmed-9761075 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97610752022-12-20 Risk factors for early mortality of lung cancer patients in France: A nationwide analysis Goussault, Hélène Gendarme, Sébastien Assié, Jean‐Baptiste Jung, Camille Epaud, Salomé Algans, Christelle Salaun‐Penquer, Noémie Rousseau, Mathilde Lazatti, Andrea Chouaïd, Christos Cancer Med RESEARCH ARTICLES BACKGROUND: Despite therapeutic advances, lung cancer remains the first cause of death from cancer. The main objective of this study was to identify risk factors associated with death within 3‐months of the first hospitalization for lung cancer in France. METHODS: This analysis included patients with a first hospitalization for lung cancer (between January 1, 2016 and December 31, 2018) according to diagnosis‐related groups entered into the French national medical‐administrative database. Clinical and socioeconomic parameters and characteristics of that first hospitalization were analyzed. A model predictive of early mortality was developed based on those variables. RESULTS: The 144,087 included patients were 67% men; median age of 68 [interquartile range 60–76] years; 47% had metastatic disease at diagnosis; and 34% and 23%, respectively, had received systemic treatment or undergone curative surgery. The 3‐month mortality was 19%, and significantly higher for those ≥70 versus <70 years old (OR 1.33, 1.22–1.45), men versus. women (OR 1.50, 1.44–1.55), those with metastatic disease at diagnosis (OR, 3.30, 3.18–3.43), first hospitalization via the emergency room (OR 1.65 1.59–1.71) and first hospitalization lasting >30 days (OR, 1.58 1.49–1.68). In contrast, no socioeconomic characteristic was associated with early mortality. CONCLUSION: Almost 1 in 5 patients diagnosed with lung cancer in France died within 3 months post‐diagnosis. Improving survival requires diagnosis at an earlier stage and better organization of diagnosis and specific care pathways. John Wiley and Sons Inc. 2022-05-14 /pmc/articles/PMC9761075/ /pubmed/35567378 http://dx.doi.org/10.1002/cam4.4821 Text en © 2022 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | RESEARCH ARTICLES Goussault, Hélène Gendarme, Sébastien Assié, Jean‐Baptiste Jung, Camille Epaud, Salomé Algans, Christelle Salaun‐Penquer, Noémie Rousseau, Mathilde Lazatti, Andrea Chouaïd, Christos Risk factors for early mortality of lung cancer patients in France: A nationwide analysis |
title | Risk factors for early mortality of lung cancer patients in France: A nationwide analysis |
title_full | Risk factors for early mortality of lung cancer patients in France: A nationwide analysis |
title_fullStr | Risk factors for early mortality of lung cancer patients in France: A nationwide analysis |
title_full_unstemmed | Risk factors for early mortality of lung cancer patients in France: A nationwide analysis |
title_short | Risk factors for early mortality of lung cancer patients in France: A nationwide analysis |
title_sort | risk factors for early mortality of lung cancer patients in france: a nationwide analysis |
topic | RESEARCH ARTICLES |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9761075/ https://www.ncbi.nlm.nih.gov/pubmed/35567378 http://dx.doi.org/10.1002/cam4.4821 |
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