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Hypoxia-inducible factor 1α enhances RANKL-induced osteoclast differentiation by upregulating the MAPK pathway

BACKGROUND: Hypoxia (low-oxygen tension) and excessive osteoclast activation are common conditions in many bone loss diseases, such as osteoporosis, rheumatoid arthritis (RA), and pathologic fractures. Hypoxia-inducible factor 1 alpha (HIF1α) regulates cellular responses to hypoxic conditions. Howev...

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Detalles Bibliográficos
Autores principales:	Wang, Dong, Liu, Lin, Qu, Zechao, Zhang, Bo, Gao, Xiangcheng, Huang, Wangli, Feng, Mingzhe, Gong, Yining, Kong, Lingbo, Wang, Yanjun, Yan, Liang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	AME Publishing Company 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9761153/ https://www.ncbi.nlm.nih.gov/pubmed/36544674 http://dx.doi.org/10.21037/atm-22-4603

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