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Safety and efficacy of a feed additive consisting of endo‐1,4‐beta xylanase, endo‐1,4‐beta‐glucanase and xyloglucan‐specific‐endo‐beta‐1,4‐glucanase produced by Trichoderma citrinoviride DSM 33578 (Huvezym® neXo 100 G/L) for all poultry species, ornamental birds and piglets (weaned and suckling) (Huvepharma EOOD)
Following a request from the European Commission, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of the product Huvezym® neXo 100 G/L containing an endo‐1,4‐beta xylanase, an endo‐1,4‐beta‐gluca...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9761340/ https://www.ncbi.nlm.nih.gov/pubmed/36545570 http://dx.doi.org/10.2903/j.efsa.2022.7702 |
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author | Bampidis, Vasileios Azimonti, Giovanna Bastos, Maria de Lourdes Christensen, Henrik Dusemund, Birgit Fašmon Durjava, Mojca Kouba, Maryline López‐Alonso, Marta Puente, Secundino López Marcon, Francesca Mayo, Baltasar Pechová, Alena Petkova, Mariana Ramos, Fernando Sanz, Yolanda Villa, Roberto Edoardo Woutersen, Ruud Aquilina, Gabriele Tosti, Luca Yurkov, Andrey Anguita, Montserrat Galobart, Jaume Ortuño, Jordi Pizzo, Fabiola Tarrés‐Call, Jordi Pettenati, Elisa |
author_facet | Bampidis, Vasileios Azimonti, Giovanna Bastos, Maria de Lourdes Christensen, Henrik Dusemund, Birgit Fašmon Durjava, Mojca Kouba, Maryline López‐Alonso, Marta Puente, Secundino López Marcon, Francesca Mayo, Baltasar Pechová, Alena Petkova, Mariana Ramos, Fernando Sanz, Yolanda Villa, Roberto Edoardo Woutersen, Ruud Aquilina, Gabriele Tosti, Luca Yurkov, Andrey Anguita, Montserrat Galobart, Jaume Ortuño, Jordi Pizzo, Fabiola Tarrés‐Call, Jordi Pettenati, Elisa |
collection | PubMed |
description | Following a request from the European Commission, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of the product Huvezym® neXo 100 G/L containing an endo‐1,4‐beta xylanase, an endo‐1,4‐beta‐glucanase and a xyloglucan‐specific‐endo‐beta‐1,4‐glucanase produced by a non‐genetically modified strain of Trichoderma citrinoviride (DSM 33578) as a zootechnical additive for feed in all poultry species, ornamental birds and piglets (weaned and suckling). The information regarding the production strain did not allow to confirm its taxonomic identification. The batches used for the characterisation of the final formulations showed compliance with the minimum specifications of the additive in terms of enzyme activities but showed ratios between the enzymes lower than the ones specified for the additive. The FEEDAP Panel considered that the below‐described conclusions would apply to the final formulations of the additive as per specifications with xylanase:glucanase, xylanase:xyloglucanase and glucanase:xyloglucanase ratios of 15, 15 and 1, respectively. Based on the data available, the Panel concluded that the additive is safe for the target species, consumers and the environment. Huvezym® neXo 100 G (granulated form) is neither skin corrosive nor eye irritant but should be considered a potential skin sensitiser. Huvezym® neXo 100 L (liquid) is neither skin corrosive nor sensitising and it is not an eye irritant. Due to lack of data, no conclusions can be drawn on the skin irritation of the final formulations of the additive. Due to the proteinaceous nature of the active substances, the additive is considered a respiratory sensitiser. The FEEDAP Panel concluded that the additive has the potential to be efficacious in chickens for fattening, chickens reared for laying and breeding, and all growing poultry and ornamental birds at the minimum intended level of 1,500 EPU, 100 CU and 100 XGU/kg complete feed. Owing to the lack of sufficient data, the Panel could not conclude on the efficacy of the additive for laying hens and weaned piglets. |
format | Online Article Text |
id | pubmed-9761340 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97613402022-12-20 Safety and efficacy of a feed additive consisting of endo‐1,4‐beta xylanase, endo‐1,4‐beta‐glucanase and xyloglucan‐specific‐endo‐beta‐1,4‐glucanase produced by Trichoderma citrinoviride DSM 33578 (Huvezym® neXo 100 G/L) for all poultry species, ornamental birds and piglets (weaned and suckling) (Huvepharma EOOD) Bampidis, Vasileios Azimonti, Giovanna Bastos, Maria de Lourdes Christensen, Henrik Dusemund, Birgit Fašmon Durjava, Mojca Kouba, Maryline López‐Alonso, Marta Puente, Secundino López Marcon, Francesca Mayo, Baltasar Pechová, Alena Petkova, Mariana Ramos, Fernando Sanz, Yolanda Villa, Roberto Edoardo Woutersen, Ruud Aquilina, Gabriele Tosti, Luca Yurkov, Andrey Anguita, Montserrat Galobart, Jaume Ortuño, Jordi Pizzo, Fabiola Tarrés‐Call, Jordi Pettenati, Elisa EFSA J Scientific Opinion Following a request from the European Commission, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of the product Huvezym® neXo 100 G/L containing an endo‐1,4‐beta xylanase, an endo‐1,4‐beta‐glucanase and a xyloglucan‐specific‐endo‐beta‐1,4‐glucanase produced by a non‐genetically modified strain of Trichoderma citrinoviride (DSM 33578) as a zootechnical additive for feed in all poultry species, ornamental birds and piglets (weaned and suckling). The information regarding the production strain did not allow to confirm its taxonomic identification. The batches used for the characterisation of the final formulations showed compliance with the minimum specifications of the additive in terms of enzyme activities but showed ratios between the enzymes lower than the ones specified for the additive. The FEEDAP Panel considered that the below‐described conclusions would apply to the final formulations of the additive as per specifications with xylanase:glucanase, xylanase:xyloglucanase and glucanase:xyloglucanase ratios of 15, 15 and 1, respectively. Based on the data available, the Panel concluded that the additive is safe for the target species, consumers and the environment. Huvezym® neXo 100 G (granulated form) is neither skin corrosive nor eye irritant but should be considered a potential skin sensitiser. Huvezym® neXo 100 L (liquid) is neither skin corrosive nor sensitising and it is not an eye irritant. Due to lack of data, no conclusions can be drawn on the skin irritation of the final formulations of the additive. Due to the proteinaceous nature of the active substances, the additive is considered a respiratory sensitiser. The FEEDAP Panel concluded that the additive has the potential to be efficacious in chickens for fattening, chickens reared for laying and breeding, and all growing poultry and ornamental birds at the minimum intended level of 1,500 EPU, 100 CU and 100 XGU/kg complete feed. Owing to the lack of sufficient data, the Panel could not conclude on the efficacy of the additive for laying hens and weaned piglets. John Wiley and Sons Inc. 2022-12-19 /pmc/articles/PMC9761340/ /pubmed/36545570 http://dx.doi.org/10.2903/j.efsa.2022.7702 Text en © 2022 Wiley‐VCH Verlag GmbH & Co. KgaA on behalf of the European Food Safety Authority. https://creativecommons.org/licenses/by-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nd/4.0/ (https://creativecommons.org/licenses/by-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited and no modifications or adaptations are made. |
spellingShingle | Scientific Opinion Bampidis, Vasileios Azimonti, Giovanna Bastos, Maria de Lourdes Christensen, Henrik Dusemund, Birgit Fašmon Durjava, Mojca Kouba, Maryline López‐Alonso, Marta Puente, Secundino López Marcon, Francesca Mayo, Baltasar Pechová, Alena Petkova, Mariana Ramos, Fernando Sanz, Yolanda Villa, Roberto Edoardo Woutersen, Ruud Aquilina, Gabriele Tosti, Luca Yurkov, Andrey Anguita, Montserrat Galobart, Jaume Ortuño, Jordi Pizzo, Fabiola Tarrés‐Call, Jordi Pettenati, Elisa Safety and efficacy of a feed additive consisting of endo‐1,4‐beta xylanase, endo‐1,4‐beta‐glucanase and xyloglucan‐specific‐endo‐beta‐1,4‐glucanase produced by Trichoderma citrinoviride DSM 33578 (Huvezym® neXo 100 G/L) for all poultry species, ornamental birds and piglets (weaned and suckling) (Huvepharma EOOD) |
title | Safety and efficacy of a feed additive consisting of endo‐1,4‐beta xylanase, endo‐1,4‐beta‐glucanase and xyloglucan‐specific‐endo‐beta‐1,4‐glucanase produced by Trichoderma citrinoviride
DSM 33578 (Huvezym® neXo 100 G/L) for all poultry species, ornamental birds and piglets (weaned and suckling) (Huvepharma EOOD) |
title_full | Safety and efficacy of a feed additive consisting of endo‐1,4‐beta xylanase, endo‐1,4‐beta‐glucanase and xyloglucan‐specific‐endo‐beta‐1,4‐glucanase produced by Trichoderma citrinoviride
DSM 33578 (Huvezym® neXo 100 G/L) for all poultry species, ornamental birds and piglets (weaned and suckling) (Huvepharma EOOD) |
title_fullStr | Safety and efficacy of a feed additive consisting of endo‐1,4‐beta xylanase, endo‐1,4‐beta‐glucanase and xyloglucan‐specific‐endo‐beta‐1,4‐glucanase produced by Trichoderma citrinoviride
DSM 33578 (Huvezym® neXo 100 G/L) for all poultry species, ornamental birds and piglets (weaned and suckling) (Huvepharma EOOD) |
title_full_unstemmed | Safety and efficacy of a feed additive consisting of endo‐1,4‐beta xylanase, endo‐1,4‐beta‐glucanase and xyloglucan‐specific‐endo‐beta‐1,4‐glucanase produced by Trichoderma citrinoviride
DSM 33578 (Huvezym® neXo 100 G/L) for all poultry species, ornamental birds and piglets (weaned and suckling) (Huvepharma EOOD) |
title_short | Safety and efficacy of a feed additive consisting of endo‐1,4‐beta xylanase, endo‐1,4‐beta‐glucanase and xyloglucan‐specific‐endo‐beta‐1,4‐glucanase produced by Trichoderma citrinoviride
DSM 33578 (Huvezym® neXo 100 G/L) for all poultry species, ornamental birds and piglets (weaned and suckling) (Huvepharma EOOD) |
title_sort | safety and efficacy of a feed additive consisting of endo‐1,4‐beta xylanase, endo‐1,4‐beta‐glucanase and xyloglucan‐specific‐endo‐beta‐1,4‐glucanase produced by trichoderma citrinoviride
dsm 33578 (huvezym® nexo 100 g/l) for all poultry species, ornamental birds and piglets (weaned and suckling) (huvepharma eood) |
topic | Scientific Opinion |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9761340/ https://www.ncbi.nlm.nih.gov/pubmed/36545570 http://dx.doi.org/10.2903/j.efsa.2022.7702 |
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