YH29407 with anti-PD-1 ameliorates anti-tumor effects via increased T cell functionality and antigen presenting machinery in the tumor microenvironment

Among cancer cells, indoleamine 2, 3-dioxygenase1 (IDO1) activity has been implicated in improving the proliferation and growth of cancer cells and suppressing immune cell activity. IDO1 is also responsible for the catabolism of tryptophan to kynurenine. Depletion of tryptophan and an increase in ky...

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Detalles Bibliográficos
Autores principales: Kim, Dong Kwon, Synn, Chun-Bong, Yang, Seung Min, Kang, Seongsan, Baek, Sujeong, Oh, Se-Woong, Lee, Gyu-Jin, Kang, Ho-Woong, Lee, Young-Sung, Park, Jong Suk, Kim, Jae Hwan, Byeon, Youngseon, Kim, Young Seob, Lee, Doo Jae, Kim, Hyun-Woo, Park, June Dong, Lee, Sung Sook, Lee, Ji Yun, Lee, Jii Bum, Kim, Chang Gon, Hong, Min Hee, Lim, Sun Min, Kim, Hey Ryun, Pyo, Kyoung-Ho, Cho, Byoung Chul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9761775/
https://www.ncbi.nlm.nih.gov/pubmed/36545214
http://dx.doi.org/10.3389/fchem.2022.998013

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