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Адипоцитокины: современный взгляд на дефиницию, классификацию и роль в организме
Adipose tissue is an endocrine organ which produces a large number of secretory bioactive substances also known as adipocytokines affecting directly insulin resistance (IR), glucose and lipid metabolism, angiogenesis and inflammation. The studies show a close connection between the imbalance of adip...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Endocrinology Research Centre
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9761877/ https://www.ncbi.nlm.nih.gov/pubmed/35262298 http://dx.doi.org/10.14341/probl12805 |
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author | Маркова, Т. Н. Мищенко, Н. К. Петина, Д. В. |
author_facet | Маркова, Т. Н. Мищенко, Н. К. Петина, Д. В. |
author_sort | Маркова, Т. Н. |
collection | PubMed |
description | Adipose tissue is an endocrine organ which produces a large number of secretory bioactive substances also known as adipocytokines affecting directly insulin resistance (IR), glucose and lipid metabolism, angiogenesis and inflammation. The studies show a close connection between the imbalance of adipocytokines formed as a result of excessive deposit of adipose tissue in the course of the development of type 2 diabetes mellitus and cardiovascular diseases. In the present review, we summarize current data on the effect of the adipocytokines on the liver, skeletal muscles, adipose tissue, endothelial cells and inflammatory processes, as well as attempt to define the term «adipocytokines» and classify adipocytokines according to their influence on metabolic processes and pro-inflammatory status. Some of adipocytokines (adiponectin, omentin, leptin, resistin, tumor necrosis factor-α and interleukin-6) are divided into two groups: adipocytokines reducing IR, and adipocytokines increasing IR. |
format | Online Article Text |
id | pubmed-9761877 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Endocrinology Research Centre |
record_format | MEDLINE/PubMed |
spelling | pubmed-97618772023-01-06 Адипоцитокины: современный взгляд на дефиницию, классификацию и роль в организме Маркова, Т. Н. Мищенко, Н. К. Петина, Д. В. Probl Endokrinol (Mosk) Research Article Adipose tissue is an endocrine organ which produces a large number of secretory bioactive substances also known as adipocytokines affecting directly insulin resistance (IR), glucose and lipid metabolism, angiogenesis and inflammation. The studies show a close connection between the imbalance of adipocytokines formed as a result of excessive deposit of adipose tissue in the course of the development of type 2 diabetes mellitus and cardiovascular diseases. In the present review, we summarize current data on the effect of the adipocytokines on the liver, skeletal muscles, adipose tissue, endothelial cells and inflammatory processes, as well as attempt to define the term «adipocytokines» and classify adipocytokines according to their influence on metabolic processes and pro-inflammatory status. Some of adipocytokines (adiponectin, omentin, leptin, resistin, tumor necrosis factor-α and interleukin-6) are divided into two groups: adipocytokines reducing IR, and adipocytokines increasing IR. Endocrinology Research Centre 2021-12-06 /pmc/articles/PMC9761877/ /pubmed/35262298 http://dx.doi.org/10.14341/probl12805 Text en Copyright © Endocrinology Research Centre, 2022 https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 License. |
spellingShingle | Research Article Маркова, Т. Н. Мищенко, Н. К. Петина, Д. В. Адипоцитокины: современный взгляд на дефиницию, классификацию и роль в организме |
title | Адипоцитокины: современный взгляд на дефиницию, классификацию и роль в организме |
title_full | Адипоцитокины: современный взгляд на дефиницию, классификацию и роль в организме |
title_fullStr | Адипоцитокины: современный взгляд на дефиницию, классификацию и роль в организме |
title_full_unstemmed | Адипоцитокины: современный взгляд на дефиницию, классификацию и роль в организме |
title_short | Адипоцитокины: современный взгляд на дефиницию, классификацию и роль в организме |
title_sort | адипоцитокины: современный взгляд на дефиницию, классификацию и роль в организме |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9761877/ https://www.ncbi.nlm.nih.gov/pubmed/35262298 http://dx.doi.org/10.14341/probl12805 |
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