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Адипоцитокины: современный взгляд на дефиницию, классификацию и роль в организме

Adipose tissue is an endocrine organ which produces a large number of secretory bioactive substances also known as adipocytokines affecting directly insulin resistance (IR), glucose and lipid metabolism, angiogenesis and inflammation. The studies show a close connection between the imbalance of adip...

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Autores principales: Маркова, Т. Н., Мищенко, Н. К., Петина, Д. В.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Endocrinology Research Centre 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9761877/
https://www.ncbi.nlm.nih.gov/pubmed/35262298
http://dx.doi.org/10.14341/probl12805
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author Маркова, Т. Н.
Мищенко, Н. К.
Петина, Д. В.
author_facet Маркова, Т. Н.
Мищенко, Н. К.
Петина, Д. В.
author_sort Маркова, Т. Н.
collection PubMed
description Adipose tissue is an endocrine organ which produces a large number of secretory bioactive substances also known as adipocytokines affecting directly insulin resistance (IR), glucose and lipid metabolism, angiogenesis and inflammation. The studies show a close connection between the imbalance of adipocytokines formed as a result of excessive deposit of adipose tissue in the course of the development of type 2 diabetes mellitus and cardiovascular diseases. In the present review, we summarize current data on the effect of the adipocytokines on the liver, skeletal muscles, adipose tissue, endothelial cells and inflammatory processes, as well as attempt to define the term «adipocytokines» and classify adipocytokines according to their influence on metabolic processes and pro-inflammatory status. Some of adipocytokines (adiponectin, omentin, leptin, resistin, tumor necrosis factor-α and interleukin-6) are divided into two groups: adipocytokines reducing IR, and adipocytokines increasing IR.
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spelling pubmed-97618772023-01-06 Адипоцитокины: современный взгляд на дефиницию, классификацию и роль в организме Маркова, Т. Н. Мищенко, Н. К. Петина, Д. В. Probl Endokrinol (Mosk) Research Article Adipose tissue is an endocrine organ which produces a large number of secretory bioactive substances also known as adipocytokines affecting directly insulin resistance (IR), glucose and lipid metabolism, angiogenesis and inflammation. The studies show a close connection between the imbalance of adipocytokines formed as a result of excessive deposit of adipose tissue in the course of the development of type 2 diabetes mellitus and cardiovascular diseases. In the present review, we summarize current data on the effect of the adipocytokines on the liver, skeletal muscles, adipose tissue, endothelial cells and inflammatory processes, as well as attempt to define the term «adipocytokines» and classify adipocytokines according to their influence on metabolic processes and pro-inflammatory status. Some of adipocytokines (adiponectin, omentin, leptin, resistin, tumor necrosis factor-α and interleukin-6) are divided into two groups: adipocytokines reducing IR, and adipocytokines increasing IR. Endocrinology Research Centre 2021-12-06 /pmc/articles/PMC9761877/ /pubmed/35262298 http://dx.doi.org/10.14341/probl12805 Text en Copyright © Endocrinology Research Centre, 2022 https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 License.
spellingShingle Research Article
Маркова, Т. Н.
Мищенко, Н. К.
Петина, Д. В.
Адипоцитокины: современный взгляд на дефиницию, классификацию и роль в организме
title Адипоцитокины: современный взгляд на дефиницию, классификацию и роль в организме
title_full Адипоцитокины: современный взгляд на дефиницию, классификацию и роль в организме
title_fullStr Адипоцитокины: современный взгляд на дефиницию, классификацию и роль в организме
title_full_unstemmed Адипоцитокины: современный взгляд на дефиницию, классификацию и роль в организме
title_short Адипоцитокины: современный взгляд на дефиницию, классификацию и роль в организме
title_sort адипоцитокины: современный взгляд на дефиницию, классификацию и роль в организме
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9761877/
https://www.ncbi.nlm.nih.gov/pubmed/35262298
http://dx.doi.org/10.14341/probl12805
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