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VHL-recruiting PROTAC attenuates renal fibrosis and preserves renal function via simultaneous degradation of Smad3 and stabilization of HIF-2α

BACKGROUND: Renal fibrosis is the pathological foundation of various chronic kidney diseases progressing to end stage renal failure. However, there are currently no nephroprotective drugs targeted to the fibrotic process in clinical practice. Proteolytic targeting chimeras (PROTACs), which reversibl...

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Detalles Bibliográficos
Autores principales:	Yang, Jiayi, Ruan, Yuyi, Wang, Dan, Fan, Jinjin, Luo, Ning, Chen, Huiting, Li, Xiaoyan, Chen, Wei, Wang, Xin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9761961/ https://www.ncbi.nlm.nih.gov/pubmed/36536448 http://dx.doi.org/10.1186/s13578-022-00936-x

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