Retinal toxicity of long term overdose of sildenafil citrate: A case report

PURPOSE: To report a case of eye structure changes in a patient with long-term overdose of sildenafil citrate. OBSERVATIONS: A 28-year-old male presented to our outpatient clinic with flare sensation in both eyes for 1 year after taking sildenafil citrate at a dose of 200 mg daily for two years. mER...

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Detalles Bibliográficos
Autores principales: Yan, Huichao, Yu, Wenzhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9762146/
https://www.ncbi.nlm.nih.gov/pubmed/36544750
http://dx.doi.org/10.1016/j.ajoc.2022.101761
Descripción
Sumario:PURPOSE: To report a case of eye structure changes in a patient with long-term overdose of sildenafil citrate. OBSERVATIONS: A 28-year-old male presented to our outpatient clinic with flare sensation in both eyes for 1 year after taking sildenafil citrate at a dose of 200 mg daily for two years. mERG and OCT examination revealed persistent damage of retinal photoreceptor cells. The symptoms did not disappear after 3 months off the medication. CONCLUSIONS AND IMPORTANCE: Long term excessive use of overdose sildenafil citrate can cause serious damage to retinal photoreceptor cells. The retinal side effects of sildenafil citrate still need to be further investigated, and the administration of systemic overdose also needs to be considered by all physicians, not just ophthalmologists.

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