High titre neutralizing antibodies in response to SARS–CoV–2 infection require RBD–specific CD4 T cells that include proliferative memory cells

BACKGROUND: Long-term immunity to SARS-CoV-2 infection, including neutralizing antibodies and T cell-mediated immunity, is required in a very large majority of the population in order to reduce ongoing disease burden. METHODS: We have investigated the association between memory CD4 and CD8 T cells a...

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Autores principales: Phetsouphanh, Chansavath, Khoo, Weng Hua, Jackson, Katherine, Klemm, Vera, Howe, Annett, Aggarwal, Anupriya, Akerman, Anouschka, Milogiannakis, Vanessa, Stella, Alberto Ospina, Rouet, Romain, Schofield, Peter, Faulks, Megan L., Law, Hannah, Danwilai, Thidarat, Starr, Mitchell, Munier, C. Mee Ling, Christ, Daniel, Singh, Mandeep, Croucher, Peter I., Brilot-Turville, Fabienne, Turville, Stuart, Phan, Tri Giang, Dore, Gregory J., Darley, David, Cunningham, Philip, Matthews, Gail V., Kelleher, Anthony D., Zaunders, John J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9762180/
https://www.ncbi.nlm.nih.gov/pubmed/36544780
http://dx.doi.org/10.3389/fimmu.2022.1032911

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