Cargando…

Characterization of a novel positive allosteric modulator of the α(1A)-Adrenergic receptor

α(1)-Adrenergic Receptors (ARs) are G-protein Coupled Receptors (GPCRs) that regulate the sympathetic nervous system via the binding and activation of norepinephrine (NE) and epinephrine (Epi). α(1)-ARs control various aspects of neurotransmission, cognition, cardiovascular functions as well as othe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Papay, Robert S., Macdonald, Jonathan D., Stauffer, Shaun R., Perez, Dianne M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9762201/ https://www.ncbi.nlm.nih.gov/pubmed/36544813 http://dx.doi.org/10.1016/j.crphar.2022.100142

Ejemplares similares

A PAM of the α(1A)-Adrenergic receptor rescues biomarker, long-term potentiation, and cognitive deficits in Alzheimer’s disease mouse models without effects on blood pressure
por: Papay, Robert S., et al.
Publicado: (2023)

G(s) protein peptidomimetics as allosteric modulators of the β(2)-adrenergic receptor
por: Boyhus, Lotte-Emilie, et al.
Publicado: (2018)

α(1)-Adrenergic Receptors in Neurotransmission, Synaptic Plasticity, and Cognition
por: Perez, Dianne M.
Publicado: (2020)

Current Developments on the Role of α(1)-Adrenergic Receptors in Cognition, Cardioprotection, and Metabolism
por: Perez, Dianne M.
Publicado: (2021)

Novel positive allosteric modulators of sigma-1 receptor
por: Vavers, Edijs, et al.
Publicado: (2015)

Mechanism of allosteric regulation of β(2)-adrenergic receptor by cholesterol
por: Manna, Moutusi, et al.
Publicado: (2016)

Suppression of neuroinflammation by an allosteric agonist and positive allosteric modulator of the α7 nicotinic acetylcholine receptor GAT107
por: Mizrachi, Tehila, et al.
Publicado: (2021)

Unique Positive Cooperativity Between the β-Arrestin–Biased β-Blocker Carvedilol and a Small Molecule Positive Allosteric Modulator of the β2-Adrenergic Receptor
por: Pani, Biswaranjan, et al.
Publicado: (2021)

Novel positive allosteric modulators of GABA(A) receptors with anesthetic activity
por: Maldifassi, Maria C., et al.
Publicado: (2016)

α(1)-Adrenergic Receptors: Insights into Potential Therapeutic Opportunities for COVID-19, Heart Failure, and Alzheimer’s Disease
por: Perez, Dianne M.
Publicado: (2023)

Tetrahydronaphthyridine and Dihydronaphthyridinone Ethers As Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 5 (mGlu(5))
por: Turlington, Mark, et al.
Publicado: (2014)

Modulatory Actions of the Glycine Receptor β Subunit on the Positive Allosteric Modulation of Ethanol in α2 Containing Receptors
por: Muñoz, Braulio, et al.
Publicado: (2021)

Pharmacological characterisation of S 47445, a novel positive allosteric modulator of AMPA receptors
por: Bretin, Sylvie, et al.
Publicado: (2017)

Targeting Adrenergic Receptors in Metabolic Therapies for Heart Failure
por: Perez, Dianne M.
Publicado: (2021)

Allosteric Effect of Nanobody Binding on Ligand-Specific Active States of the β2 Adrenergic Receptor
por: Chen, Yue, et al.
Publicado: (2021)

Potentiating mGluR5 function with a positive allosteric modulator enhances adaptive learning
por: Xu, Jian, et al.
Publicado: (2013)

Identification of Novel Positive Allosteric Modulators of Neurotrophin Receptors for the Treatment of Cognitive Dysfunction
por: Dahlström, Märta, et al.
Publicado: (2021)

Identification by virtual screening and functional characterisation of novel positive and negative allosteric modulators of the α7 nicotinic acetylcholine receptor
por: Smelt, Charles L.C., et al.
Publicado: (2018)

Generation of nanobodies acting as silent and positive allosteric modulators of the α7 nicotinic acetylcholine receptor
por: Li, Qimeng, et al.
Publicado: (2023)

Widespread Changes in Positive Allosteric Modulation of the Muscarinic M(1) Receptor in Some Participants With Schizophrenia
por: Hopper, Shaun, et al.
Publicado: (2019)

Announcing the novel class of GABA–A receptor selective positive allosteric modulator antidepressants
por: Fasipe, Olumuyiwa John, et al.
Publicado: (2020)

Molecular Sites for the Positive Allosteric Modulation of Glycine Receptors by Endocannabinoids
por: Yévenes, Gonzalo E., et al.
Publicado: (2011)

Are AMPA Receptor Positive Allosteric Modulators Potential Pharmacotherapeutics for Addiction?
por: Watterson, Lucas R., et al.
Publicado: (2013)

Mutational Analysis of Anesthetic Binding Sites and Their Effects on GABA(A) Receptor Activation and Modulation by Positive Allosteric Modulators of the α7 Nicotinic Receptor
por: Pierce, Spencer R., et al.
Publicado: (2023)

Investigation of allosteric coupling in human β(2)-adrenergic receptor in the presence of intracellular loop 3
por: Ozgur, Canan, et al.
Publicado: (2016)

Novel Positive Allosteric Modulators of µ Opioid Receptor—Insight from In Silico and In Vivo Studies
por: Bartuzi, Damian, et al.
Publicado: (2020)

Allosteric modulation of adenosine receptors
por: Göblyös, Anikó, et al.
Publicado: (2008)

Allosteric Modulation of Chemoattractant Receptors
por: Allegretti, Marcello, et al.
Publicado: (2016)

Allosteric modulation of gonadotropin receptors
por: Lazzaretti, Clara, et al.
Publicado: (2023)

Ignavine: a novel allosteric modulator of the μ opioid receptor
por: Ohbuchi, Katsuya, et al.
Publicado: (2016)

Conformational changes in α7 acetylcholine receptors underlying allosteric modulation by divalent cations
por: McLaughlin, James T, et al.
Publicado: (2009)

Positive Allosteric Modulation of Insect Olfactory Receptor Function by ORco Agonists
por: Tsitoura, Panagiota, et al.
Publicado: (2016)

Proposed Mode of Binding and Action of Positive Allosteric Modulators at Opioid Receptors
por: Shang, Yi, et al.
Publicado: (2016)

The Molecular Mechanism of Positive Allosteric Modulation at the Dopamine D1 Receptor
por: Goldberg, Alexander, et al.
Publicado: (2023)

The molecular mechanism of positive allosteric modulation at the dopamine D1 receptor
por: Goldberg, Alexander, et al.
Publicado: (2023)

Positive allosteric modulation of TRPV1 as a novel analgesic mechanism
por: Lebovitz, Evan E, et al.
Publicado: (2012)

Sex-Dependent Anti-Stress Effect of an α5 Subunit Containing GABA(A) Receptor Positive Allosteric Modulator
por: Piantadosi, Sean C., et al.
Publicado: (2016)

Novel positive allosteric modulators of A(2B) adenosine receptor acting as bone mineralisation promoters
por: Barresi, Elisabetta, et al.
Publicado: (2020)

Positive allosteric modulation of the adenosine A(2a) receptor attenuates inflammation
por: Welihinda, Ajith A, et al.
Publicado: (2014)

Enantioenriched Positive Allosteric Modulators Display Distinct Pharmacology at the Dopamine D(1) Receptor
por: Fyfe, Tim J., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_t1kr980du9er6uhn9n0f41p0jq