Clinical Course of Two Patients with COVID-19 Respiratory Failure After Administration of the Anticancer Small Molecule, RRx-001

Two critically ill COVID-19 infected patients, who had exhausted all available treatment options, were treated with the small-molecule RRx-001 with subsequent improvement. RRx-001, a first-in-class small molecule with anti-inflammatory, vascular normalizing and macrophage-repolarizing properties, ha...

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Autores principales: Hammond, Terese Catherine, Lee, Raymond C, Oronsky, Bryan, Reid, Tony R, Caroen, Scott, Juarez, Tiffany M, Gill, Jaya, Heng, Annie, Kesari, Santosh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Case Series
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9762260/
https://www.ncbi.nlm.nih.gov/pubmed/36545548
http://dx.doi.org/10.2147/IMCRJ.S389690
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author Hammond, Terese Catherine
Lee, Raymond C
Oronsky, Bryan
Reid, Tony R
Caroen, Scott
Juarez, Tiffany M
Gill, Jaya
Heng, Annie
Kesari, Santosh
author_facet Hammond, Terese Catherine
Lee, Raymond C
Oronsky, Bryan
Reid, Tony R
Caroen, Scott
Juarez, Tiffany M
Gill, Jaya
Heng, Annie
Kesari, Santosh
author_sort Hammond, Terese Catherine
collection PubMed
description Two critically ill COVID-19 infected patients, who had exhausted all available treatment options, were treated with the small-molecule RRx-001 with subsequent improvement. RRx-001, a first-in-class small molecule with anti-inflammatory, vascular normalizing and macrophage-repolarizing properties, has been safely administered 300+ patients in clinical trials. This is the first report of RRx-001 treatment of COVID-19.
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spelling pubmed-97622602022-12-20 Clinical Course of Two Patients with COVID-19 Respiratory Failure After Administration of the Anticancer Small Molecule, RRx-001 Hammond, Terese Catherine Lee, Raymond C Oronsky, Bryan Reid, Tony R Caroen, Scott Juarez, Tiffany M Gill, Jaya Heng, Annie Kesari, Santosh Int Med Case Rep J Case Series Two critically ill COVID-19 infected patients, who had exhausted all available treatment options, were treated with the small-molecule RRx-001 with subsequent improvement. RRx-001, a first-in-class small molecule with anti-inflammatory, vascular normalizing and macrophage-repolarizing properties, has been safely administered 300+ patients in clinical trials. This is the first report of RRx-001 treatment of COVID-19. Dove 2022-12-15 /pmc/articles/PMC9762260/ /pubmed/36545548 http://dx.doi.org/10.2147/IMCRJ.S389690 Text en © 2022 Hammond et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Case Series
Hammond, Terese Catherine
Lee, Raymond C
Oronsky, Bryan
Reid, Tony R
Caroen, Scott
Juarez, Tiffany M
Gill, Jaya
Heng, Annie
Kesari, Santosh
Clinical Course of Two Patients with COVID-19 Respiratory Failure After Administration of the Anticancer Small Molecule, RRx-001
title Clinical Course of Two Patients with COVID-19 Respiratory Failure After Administration of the Anticancer Small Molecule, RRx-001
title_full Clinical Course of Two Patients with COVID-19 Respiratory Failure After Administration of the Anticancer Small Molecule, RRx-001
title_fullStr Clinical Course of Two Patients with COVID-19 Respiratory Failure After Administration of the Anticancer Small Molecule, RRx-001
title_full_unstemmed Clinical Course of Two Patients with COVID-19 Respiratory Failure After Administration of the Anticancer Small Molecule, RRx-001
title_short Clinical Course of Two Patients with COVID-19 Respiratory Failure After Administration of the Anticancer Small Molecule, RRx-001
title_sort clinical course of two patients with covid-19 respiratory failure after administration of the anticancer small molecule, rrx-001
topic Case Series
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9762260/
https://www.ncbi.nlm.nih.gov/pubmed/36545548
http://dx.doi.org/10.2147/IMCRJ.S389690
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