Gossypol Broadly Inhibits Coronaviruses by Targeting RNA‐Dependent RNA Polymerases (Adv. Sci. 35/2022)

RNA‐Dependent RNA Polymerase In article number 2203499, Zhigao Bu, Lingbo Qu, Maozhi Ren, Fuguang Li, and co‐workers report that gossypol, a natural product from cotton plant, can efficiently inhibit SARS‐CoV‐2 variants by targeting RNA‐dependent RNA polymerase (RdRp). Moreover, the RdRp inhibitor gossypol shows broad‐spectrum antiviral activity against the examined coronaviruses from the four main phylogenetic branches alphacoronaviruses, betacoronaviruses, gammacoronaviruses, and deltacoronaviruses. [Image: see text]