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Gossypol Broadly Inhibits Coronaviruses by Targeting RNA‐Dependent RNA Polymerases (Adv. Sci. 35/2022)
RNA‐Dependent RNA Polymerase In article number 2203499, Zhigao Bu, Lingbo Qu, Maozhi Ren, Fuguang Li, and co‐workers report that gossypol, a natural product from cotton plant, can efficiently inhibit SARS‐CoV‐2 variants by targeting RNA‐dependent RNA polymerase (RdRp). Moreover, the RdRp inhibitor g...
| Autores principales: | , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9762278/ http://dx.doi.org/10.1002/advs.202270222 |
| _version_ | 1784852830408933376 |
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| author | Wang, Wenjing Li, Wenkang Wen, Zhiyuan Wang, Chong Liu, Weilong Zhang, Yufang Liu, Juncheng Ding, Tianze Shuai, Lei Zhong, Gongxun Bu, Zhigao Qu, Lingbo Ren, Maozhi Li, Fuguang |
| author_facet | Wang, Wenjing Li, Wenkang Wen, Zhiyuan Wang, Chong Liu, Weilong Zhang, Yufang Liu, Juncheng Ding, Tianze Shuai, Lei Zhong, Gongxun Bu, Zhigao Qu, Lingbo Ren, Maozhi Li, Fuguang |
| author_sort | Wang, Wenjing |
| collection | PubMed |
| description | RNA‐Dependent RNA Polymerase In article number 2203499, Zhigao Bu, Lingbo Qu, Maozhi Ren, Fuguang Li, and co‐workers report that gossypol, a natural product from cotton plant, can efficiently inhibit SARS‐CoV‐2 variants by targeting RNA‐dependent RNA polymerase (RdRp). Moreover, the RdRp inhibitor gossypol shows broad‐spectrum antiviral activity against the examined coronaviruses from the four main phylogenetic branches alphacoronaviruses, betacoronaviruses, gammacoronaviruses, and deltacoronaviruses. [Image: see text] |
| format | Online Article Text |
| id | pubmed-9762278 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | John Wiley and Sons Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-97622782022-12-20 Gossypol Broadly Inhibits Coronaviruses by Targeting RNA‐Dependent RNA Polymerases (Adv. Sci. 35/2022) Wang, Wenjing Li, Wenkang Wen, Zhiyuan Wang, Chong Liu, Weilong Zhang, Yufang Liu, Juncheng Ding, Tianze Shuai, Lei Zhong, Gongxun Bu, Zhigao Qu, Lingbo Ren, Maozhi Li, Fuguang Adv Sci (Weinh) Inside Front Cover RNA‐Dependent RNA Polymerase In article number 2203499, Zhigao Bu, Lingbo Qu, Maozhi Ren, Fuguang Li, and co‐workers report that gossypol, a natural product from cotton plant, can efficiently inhibit SARS‐CoV‐2 variants by targeting RNA‐dependent RNA polymerase (RdRp). Moreover, the RdRp inhibitor gossypol shows broad‐spectrum antiviral activity against the examined coronaviruses from the four main phylogenetic branches alphacoronaviruses, betacoronaviruses, gammacoronaviruses, and deltacoronaviruses. [Image: see text] John Wiley and Sons Inc. 2022-12-19 /pmc/articles/PMC9762278/ http://dx.doi.org/10.1002/advs.202270222 Text en © 2022 Wiley‐VCH GmbH https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
| spellingShingle | Inside Front Cover Wang, Wenjing Li, Wenkang Wen, Zhiyuan Wang, Chong Liu, Weilong Zhang, Yufang Liu, Juncheng Ding, Tianze Shuai, Lei Zhong, Gongxun Bu, Zhigao Qu, Lingbo Ren, Maozhi Li, Fuguang Gossypol Broadly Inhibits Coronaviruses by Targeting RNA‐Dependent RNA Polymerases (Adv. Sci. 35/2022) |
| title | Gossypol Broadly Inhibits Coronaviruses by Targeting RNA‐Dependent RNA Polymerases (Adv. Sci. 35/2022) |
| title_full | Gossypol Broadly Inhibits Coronaviruses by Targeting RNA‐Dependent RNA Polymerases (Adv. Sci. 35/2022) |
| title_fullStr | Gossypol Broadly Inhibits Coronaviruses by Targeting RNA‐Dependent RNA Polymerases (Adv. Sci. 35/2022) |
| title_full_unstemmed | Gossypol Broadly Inhibits Coronaviruses by Targeting RNA‐Dependent RNA Polymerases (Adv. Sci. 35/2022) |
| title_short | Gossypol Broadly Inhibits Coronaviruses by Targeting RNA‐Dependent RNA Polymerases (Adv. Sci. 35/2022) |
| title_sort | gossypol broadly inhibits coronaviruses by targeting rna‐dependent rna polymerases (adv. sci. 35/2022) |
| topic | Inside Front Cover |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9762278/ http://dx.doi.org/10.1002/advs.202270222 |
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