Cargando…

Wearable Photomedicine for Neonatal Jaundice Treatment Using Blue Organic Light‐Emitting Diodes (OLEDs): Toward Textile‐Based Wearable Phototherapeutics

Neonatal jaundice is a very common disease in newborns and can lead to brain damage or death in severe cases. Phototherapy with light‐emitting diode (LED) arrays is widely used as the easiest and fastest way to relieve jaundice in newborns, but it has distinct disadvantages such as loss of water in...

Descripción completa

Detalles Bibliográficos
Autores principales: Choi, Seungyeop, Jeon, Yongmin, Kwon, Jeong Hyun, Ihm, Chunhwa, Kim, Seung Yeon, Choi, Kyung Cheol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9762290/
https://www.ncbi.nlm.nih.gov/pubmed/36310107
http://dx.doi.org/10.1002/advs.202204622
_version_ 1784852833362771968
author Choi, Seungyeop
Jeon, Yongmin
Kwon, Jeong Hyun
Ihm, Chunhwa
Kim, Seung Yeon
Choi, Kyung Cheol
author_facet Choi, Seungyeop
Jeon, Yongmin
Kwon, Jeong Hyun
Ihm, Chunhwa
Kim, Seung Yeon
Choi, Kyung Cheol
author_sort Choi, Seungyeop
collection PubMed
description Neonatal jaundice is a very common disease in newborns and can lead to brain damage or death in severe cases. Phototherapy with light‐emitting diode (LED) arrays is widely used as the easiest and fastest way to relieve jaundice in newborns, but it has distinct disadvantages such as loss of water in the patient, damage to the retina, and separation from parents. In this paper, a novel light source‐based phototherapy for neonatal jaundice is proposed using a textile‐based wearable organic light‐emitting diode (OLED) platform that can move flexibly and conform to the curvature of the human body. The soft and flexible textile‐based blue OLED platform is designed to have a peak wavelength of 470 nm, suitable for jaundice treatment, and shows performance (>20 µW cm(−2) nm(−) (1)) suitable for intensive jaundice treatment even at low voltage (<4.0 V). The textile‐based OLEDs fabricated in this study exhibit an operating reliability of over 100 h and low‐temperature operation (<35 °C). The results of an in vitro jaundice treatment test using a large‐area blue OLED confirm that the bilirubin level decreases to 12 mg dL(−1) with 3 h of OLED irradiation.
format Online
Article
Text
id pubmed-9762290
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-97622902022-12-20 Wearable Photomedicine for Neonatal Jaundice Treatment Using Blue Organic Light‐Emitting Diodes (OLEDs): Toward Textile‐Based Wearable Phototherapeutics Choi, Seungyeop Jeon, Yongmin Kwon, Jeong Hyun Ihm, Chunhwa Kim, Seung Yeon Choi, Kyung Cheol Adv Sci (Weinh) Research Articles Neonatal jaundice is a very common disease in newborns and can lead to brain damage or death in severe cases. Phototherapy with light‐emitting diode (LED) arrays is widely used as the easiest and fastest way to relieve jaundice in newborns, but it has distinct disadvantages such as loss of water in the patient, damage to the retina, and separation from parents. In this paper, a novel light source‐based phototherapy for neonatal jaundice is proposed using a textile‐based wearable organic light‐emitting diode (OLED) platform that can move flexibly and conform to the curvature of the human body. The soft and flexible textile‐based blue OLED platform is designed to have a peak wavelength of 470 nm, suitable for jaundice treatment, and shows performance (>20 µW cm(−2) nm(−) (1)) suitable for intensive jaundice treatment even at low voltage (<4.0 V). The textile‐based OLEDs fabricated in this study exhibit an operating reliability of over 100 h and low‐temperature operation (<35 °C). The results of an in vitro jaundice treatment test using a large‐area blue OLED confirm that the bilirubin level decreases to 12 mg dL(−1) with 3 h of OLED irradiation. John Wiley and Sons Inc. 2022-10-30 /pmc/articles/PMC9762290/ /pubmed/36310107 http://dx.doi.org/10.1002/advs.202204622 Text en © 2022 The Authors. Advanced Science published by Wiley‐VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Choi, Seungyeop
Jeon, Yongmin
Kwon, Jeong Hyun
Ihm, Chunhwa
Kim, Seung Yeon
Choi, Kyung Cheol
Wearable Photomedicine for Neonatal Jaundice Treatment Using Blue Organic Light‐Emitting Diodes (OLEDs): Toward Textile‐Based Wearable Phototherapeutics
title Wearable Photomedicine for Neonatal Jaundice Treatment Using Blue Organic Light‐Emitting Diodes (OLEDs): Toward Textile‐Based Wearable Phototherapeutics
title_full Wearable Photomedicine for Neonatal Jaundice Treatment Using Blue Organic Light‐Emitting Diodes (OLEDs): Toward Textile‐Based Wearable Phototherapeutics
title_fullStr Wearable Photomedicine for Neonatal Jaundice Treatment Using Blue Organic Light‐Emitting Diodes (OLEDs): Toward Textile‐Based Wearable Phototherapeutics
title_full_unstemmed Wearable Photomedicine for Neonatal Jaundice Treatment Using Blue Organic Light‐Emitting Diodes (OLEDs): Toward Textile‐Based Wearable Phototherapeutics
title_short Wearable Photomedicine for Neonatal Jaundice Treatment Using Blue Organic Light‐Emitting Diodes (OLEDs): Toward Textile‐Based Wearable Phototherapeutics
title_sort wearable photomedicine for neonatal jaundice treatment using blue organic light‐emitting diodes (oleds): toward textile‐based wearable phototherapeutics
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9762290/
https://www.ncbi.nlm.nih.gov/pubmed/36310107
http://dx.doi.org/10.1002/advs.202204622
work_keys_str_mv AT choiseungyeop wearablephotomedicineforneonataljaundicetreatmentusingblueorganiclightemittingdiodesoledstowardtextilebasedwearablephototherapeutics
AT jeonyongmin wearablephotomedicineforneonataljaundicetreatmentusingblueorganiclightemittingdiodesoledstowardtextilebasedwearablephototherapeutics
AT kwonjeonghyun wearablephotomedicineforneonataljaundicetreatmentusingblueorganiclightemittingdiodesoledstowardtextilebasedwearablephototherapeutics
AT ihmchunhwa wearablephotomedicineforneonataljaundicetreatmentusingblueorganiclightemittingdiodesoledstowardtextilebasedwearablephototherapeutics
AT kimseungyeon wearablephotomedicineforneonataljaundicetreatmentusingblueorganiclightemittingdiodesoledstowardtextilebasedwearablephototherapeutics
AT choikyungcheol wearablephotomedicineforneonataljaundicetreatmentusingblueorganiclightemittingdiodesoledstowardtextilebasedwearablephototherapeutics