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Molecular Characteristics of Repotrectinib That Enable Potent Inhibition of TRK Fusion Proteins and Resistant Mutations

NTRK chromosomal rearrangements yield oncogenic TRK fusion proteins that are sensitive to TRK inhibitors (larotrectinib and entrectinib) but often mutate, limiting the durability of response for NTRK(+) patients. Next-generation inhibitors with compact macrocyclic structures (repotrectinib and selit...

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Detalles Bibliográficos
Autores principales:	Murray, Brion W., Rogers, Evan, Zhai, Dayong, Deng, Wei, Chen, Xi, Sprengeler, Paul A., Zhang, Xin, Graber, Armin, Reich, Siegfried H., Stopatschinskaja, Shanna, Solomon, Benjamin, Besse, Benjamin, Drilon, Alexander
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2021
Materias:	Small Molecule Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9762329/ https://www.ncbi.nlm.nih.gov/pubmed/34625502 http://dx.doi.org/10.1158/1535-7163.MCT-21-0632

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