RTK-Dependent Inducible Degradation of Mutant PI3Kα Drives GDC-0077 (Inavolisib) Efficacy

PIK3CA is one of the most frequently mutated oncogenes; the p110a protein it encodes plays a central role in tumor cell proliferation. Small-molecule inhibitors targeting the PI3K p110a catalytic subunit have entered clinical trials, with early-phase GDC-0077 studies showing antitumor activity and a...

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Detalles Bibliográficos
Autores principales: Song, Kyung W., Edgar, Kyle A., Hanan, Emily J., Hafner, Marc, Oeh, Jason, Merchant, Mark, Sampath, Deepak, Nannini, Michelle A., Hong, Rebecca, Phu, Lilian, Forrest, William F., Stawiski, Eric, Schmidt, Stephen, Endres, Nicholas, Guan, Jane, Wallin, Jeffrey J., Cheong, Jonathan, Plise, Emile G., Lewis Phillips, Gail D., Salphati, Laurent, Heffron, Timothy P., Olivero, Alan G., Malek, Shiva, Staben, Steven T., Kirkpatrick, Donald S., Dey, Anwesha, Friedman, Lori S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9762331/
https://www.ncbi.nlm.nih.gov/pubmed/34544753
http://dx.doi.org/10.1158/2159-8290.CD-21-0072

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