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Effect of water diuresis with hydrogen saturation on the course of acute kidney damage during the separation of oxidation and phosphorylation

Molecular hydrogen has the ability to penetrate cells, easily reach mitochondria, overcome body barriers, penetrate areas of ischemia, edema and inflammation, improve energy supply by supplying additional electrons and have antioxidant and anti-inflammatory effects by neutralizing highly reactive hy...

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Autores principales: Rohovyi, Yurii Yevgenivich, Tsitrin, Volf Yakovich, Bilookiy, Vyacheslav Vasilievich, Sheremet, Michail Ivanovich, Kolesnik, Oksana Volodimirivna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Carol Davila University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9762360/
https://www.ncbi.nlm.nih.gov/pubmed/36567846
http://dx.doi.org/10.25122/jml-2022-0155
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author Rohovyi, Yurii Yevgenivich
Tsitrin, Volf Yakovich
Bilookiy, Vyacheslav Vasilievich
Sheremet, Michail Ivanovich
Kolesnik, Oksana Volodimirivna
author_facet Rohovyi, Yurii Yevgenivich
Tsitrin, Volf Yakovich
Bilookiy, Vyacheslav Vasilievich
Sheremet, Michail Ivanovich
Kolesnik, Oksana Volodimirivna
author_sort Rohovyi, Yurii Yevgenivich
collection PubMed
description Molecular hydrogen has the ability to penetrate cells, easily reach mitochondria, overcome body barriers, penetrate areas of ischemia, edema and inflammation, improve energy supply by supplying additional electrons and have antioxidant and anti-inflammatory effects by neutralizing highly reactive hydroxyl radical and peroxynitrite. In this experiment, we included 60 nonlinear male rats weighing 0.16–0.18 kg and investigated the effect of a negative redox potential solution -297.3±5.27 mV with a molecular hydrogen saturation of 1.2 ppm on the functional-biochemical processes of the kidneys in tissue hypoxia in moderately resistant rats during the separation of oxidation and phosphorylation with the introduction of 2,4-dinitrophenol at a dose of 3 mg/kg. All studies were performed on moderately stable rats. Experimental, functional, biochemical, enzyme-linked immunosorbent, physicochemical, histoenzymochemical, and statistical research methods were used. Under conditions of renal hypoxia in the separation of oxidation and phosphorylation, the use of a solution of negative redox reabsorption of sodium ions in the distal nephron reduces the manifestations of tubular proteinuria, increases the activity of succinate dehydrogenase in the proximal nephron and reduces the redox potential of urine to negative values. Negative redox potential solution with molecular hydrogen saturation has a protective effect on the kidneys and reduces elevated levels of proinflammatory cytokines of tumor necrosis factor-α, interleukin-1-β, and interleukin-6 in blood plasma, and causes oxidative modification of proteins in the renal cortex for their hypoxia in the separation of oxidation and phosphorylation.
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spelling pubmed-97623602023-01-01 Effect of water diuresis with hydrogen saturation on the course of acute kidney damage during the separation of oxidation and phosphorylation Rohovyi, Yurii Yevgenivich Tsitrin, Volf Yakovich Bilookiy, Vyacheslav Vasilievich Sheremet, Michail Ivanovich Kolesnik, Oksana Volodimirivna J Med Life Original Article Molecular hydrogen has the ability to penetrate cells, easily reach mitochondria, overcome body barriers, penetrate areas of ischemia, edema and inflammation, improve energy supply by supplying additional electrons and have antioxidant and anti-inflammatory effects by neutralizing highly reactive hydroxyl radical and peroxynitrite. In this experiment, we included 60 nonlinear male rats weighing 0.16–0.18 kg and investigated the effect of a negative redox potential solution -297.3±5.27 mV with a molecular hydrogen saturation of 1.2 ppm on the functional-biochemical processes of the kidneys in tissue hypoxia in moderately resistant rats during the separation of oxidation and phosphorylation with the introduction of 2,4-dinitrophenol at a dose of 3 mg/kg. All studies were performed on moderately stable rats. Experimental, functional, biochemical, enzyme-linked immunosorbent, physicochemical, histoenzymochemical, and statistical research methods were used. Under conditions of renal hypoxia in the separation of oxidation and phosphorylation, the use of a solution of negative redox reabsorption of sodium ions in the distal nephron reduces the manifestations of tubular proteinuria, increases the activity of succinate dehydrogenase in the proximal nephron and reduces the redox potential of urine to negative values. Negative redox potential solution with molecular hydrogen saturation has a protective effect on the kidneys and reduces elevated levels of proinflammatory cytokines of tumor necrosis factor-α, interleukin-1-β, and interleukin-6 in blood plasma, and causes oxidative modification of proteins in the renal cortex for their hypoxia in the separation of oxidation and phosphorylation. Carol Davila University Press 2022-11 /pmc/articles/PMC9762360/ /pubmed/36567846 http://dx.doi.org/10.25122/jml-2022-0155 Text en ©2022 JOURNAL of MEDICINE and LIFE https://creativecommons.org/licenses/by/3.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/ (https://creativecommons.org/licenses/by/3.0/) ), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Original Article
Rohovyi, Yurii Yevgenivich
Tsitrin, Volf Yakovich
Bilookiy, Vyacheslav Vasilievich
Sheremet, Michail Ivanovich
Kolesnik, Oksana Volodimirivna
Effect of water diuresis with hydrogen saturation on the course of acute kidney damage during the separation of oxidation and phosphorylation
title Effect of water diuresis with hydrogen saturation on the course of acute kidney damage during the separation of oxidation and phosphorylation
title_full Effect of water diuresis with hydrogen saturation on the course of acute kidney damage during the separation of oxidation and phosphorylation
title_fullStr Effect of water diuresis with hydrogen saturation on the course of acute kidney damage during the separation of oxidation and phosphorylation
title_full_unstemmed Effect of water diuresis with hydrogen saturation on the course of acute kidney damage during the separation of oxidation and phosphorylation
title_short Effect of water diuresis with hydrogen saturation on the course of acute kidney damage during the separation of oxidation and phosphorylation
title_sort effect of water diuresis with hydrogen saturation on the course of acute kidney damage during the separation of oxidation and phosphorylation
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9762360/
https://www.ncbi.nlm.nih.gov/pubmed/36567846
http://dx.doi.org/10.25122/jml-2022-0155
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