Three on Three: Universal and High-Affinity Molecular Recognition of the Symmetric Homotrimeric Spike Protein of SARS-CoV-2 with a Symmetric Homotrimeric Aptamer

[Image: see text] Our previously discovered monomeric aptamer for SARS-CoV-2 (MSA52) possesses a universal affinity for COVID-19 spike protein variants but is ultimately limited by its ability to bind only one subunit of the spike protein. The symmetrical shape of the homotrimeric SARS-CoV-2 spike p...

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Detalles Bibliográficos
Autores principales: Li, Jiuxing, Zhang, Zijie, Gu, Jimmy, Amini, Ryan, Mansfield, Alexandria G., Xia, Jianrun, White, Dawn, Stacey, Hannah D., Ang, Jann C., Panesar, Gurpreet, Capretta, Alfredo, Filipe, Carlos D. M., Mossman, Karen, Salena, Bruno J., Gubbay, Jonathan B., Balion, Cynthia, Soleymani, Leyla, Miller, Matthew S., Yamamura, Deborah, Brennan, John D., Li, Yingfu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9762500/
https://www.ncbi.nlm.nih.gov/pubmed/36520671
http://dx.doi.org/10.1021/jacs.2c09870

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