Cargando…
Plasma Matrix Metalloproteinase-1 as a Prognostic Biomarker in Oral Cavity Squamous Cell Carcinoma
PURPOSE: Plasma matrix metalloproteinase-1 (MMP-1) is a collagenase encoded by the MMP-1 gene. However, the prognostic value of plasma MMP-1 levels in oral cavity squamous cell carcinoma (OSCC) has yet to be elucidated. The study is the first to use a cohort of OSCC patients to assess the associatio...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9762675/ https://www.ncbi.nlm.nih.gov/pubmed/36545225 http://dx.doi.org/10.2147/CMAR.S389742 |
_version_ | 1784852912912990208 |
---|---|
author | Tsai, Tsung-You Kao, Huang-Kai Huang, Yenlin Chang, Ya-Ting Young, Chi-Kuang Hung, Shao-Yu Chang, Yu-Sun Yu, Jau-Song Chang, Kai-Ping |
author_facet | Tsai, Tsung-You Kao, Huang-Kai Huang, Yenlin Chang, Ya-Ting Young, Chi-Kuang Hung, Shao-Yu Chang, Yu-Sun Yu, Jau-Song Chang, Kai-Ping |
author_sort | Tsai, Tsung-You |
collection | PubMed |
description | PURPOSE: Plasma matrix metalloproteinase-1 (MMP-1) is a collagenase encoded by the MMP-1 gene. However, the prognostic value of plasma MMP-1 levels in oral cavity squamous cell carcinoma (OSCC) has yet to be elucidated. The study is the first to use a cohort of OSCC patients to assess the association of plasma MMP-1 levels with clinicopathological factors/survival outcomes in OSCC patients. PATIENTS AND METHODS: A total of 677 patients were retrospectively enrolled, including 276 oral potentially malignant disease (OPMD) and 401 OSCC patients from 2013 to 2021. Pretreatment plasma MMP-1 levels were measured with an enzyme-linked immunosorbent assay, and the values were compared between OPMD and OSCC patients. Furthermore, the association of plasma MMP-1 levels and clinicopathological characteristics/survival outcomes in OSCC patients was investigated. RESULTS: Plasma MMP-1 levels were significantly higher in OSCC patients than in OPMD patients (p = 0.04). In the OSCC group, plasma MMP-1 levels were significantly higher in females, tumor depth ≥10 mm, advanced pT classification and advanced overall stage (p = 0.04, <0.001, <0.001, 0.002, respectively). Higher plasma MMP-1 levels were significantly associated with poorer overall, disease-specific, disease-free, locoregional recurrence-free and distant metastasis-free survival (p = 0.003, 0.02, 0.005, 0.01, 0.001, respectively). Multivariate analysis revealed that plasma MMP-1 levels were a significant predictor for overall, disease-free, and distant metastasis-free survival (p = 0.03, 0.02, and 0.010, respectively). CONCLUSION: Plasma MMP-1 levels are associated with more severe clinicopathological manifestations and can also be regarded as a significant prognostic factor for OSCC posttreatment outcomes. |
format | Online Article Text |
id | pubmed-9762675 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-97626752022-12-20 Plasma Matrix Metalloproteinase-1 as a Prognostic Biomarker in Oral Cavity Squamous Cell Carcinoma Tsai, Tsung-You Kao, Huang-Kai Huang, Yenlin Chang, Ya-Ting Young, Chi-Kuang Hung, Shao-Yu Chang, Yu-Sun Yu, Jau-Song Chang, Kai-Ping Cancer Manag Res Original Research PURPOSE: Plasma matrix metalloproteinase-1 (MMP-1) is a collagenase encoded by the MMP-1 gene. However, the prognostic value of plasma MMP-1 levels in oral cavity squamous cell carcinoma (OSCC) has yet to be elucidated. The study is the first to use a cohort of OSCC patients to assess the association of plasma MMP-1 levels with clinicopathological factors/survival outcomes in OSCC patients. PATIENTS AND METHODS: A total of 677 patients were retrospectively enrolled, including 276 oral potentially malignant disease (OPMD) and 401 OSCC patients from 2013 to 2021. Pretreatment plasma MMP-1 levels were measured with an enzyme-linked immunosorbent assay, and the values were compared between OPMD and OSCC patients. Furthermore, the association of plasma MMP-1 levels and clinicopathological characteristics/survival outcomes in OSCC patients was investigated. RESULTS: Plasma MMP-1 levels were significantly higher in OSCC patients than in OPMD patients (p = 0.04). In the OSCC group, plasma MMP-1 levels were significantly higher in females, tumor depth ≥10 mm, advanced pT classification and advanced overall stage (p = 0.04, <0.001, <0.001, 0.002, respectively). Higher plasma MMP-1 levels were significantly associated with poorer overall, disease-specific, disease-free, locoregional recurrence-free and distant metastasis-free survival (p = 0.003, 0.02, 0.005, 0.01, 0.001, respectively). Multivariate analysis revealed that plasma MMP-1 levels were a significant predictor for overall, disease-free, and distant metastasis-free survival (p = 0.03, 0.02, and 0.010, respectively). CONCLUSION: Plasma MMP-1 levels are associated with more severe clinicopathological manifestations and can also be regarded as a significant prognostic factor for OSCC posttreatment outcomes. Dove 2022-12-15 /pmc/articles/PMC9762675/ /pubmed/36545225 http://dx.doi.org/10.2147/CMAR.S389742 Text en © 2022 Tsai et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Tsai, Tsung-You Kao, Huang-Kai Huang, Yenlin Chang, Ya-Ting Young, Chi-Kuang Hung, Shao-Yu Chang, Yu-Sun Yu, Jau-Song Chang, Kai-Ping Plasma Matrix Metalloproteinase-1 as a Prognostic Biomarker in Oral Cavity Squamous Cell Carcinoma |
title | Plasma Matrix Metalloproteinase-1 as a Prognostic Biomarker in Oral Cavity Squamous Cell Carcinoma |
title_full | Plasma Matrix Metalloproteinase-1 as a Prognostic Biomarker in Oral Cavity Squamous Cell Carcinoma |
title_fullStr | Plasma Matrix Metalloproteinase-1 as a Prognostic Biomarker in Oral Cavity Squamous Cell Carcinoma |
title_full_unstemmed | Plasma Matrix Metalloproteinase-1 as a Prognostic Biomarker in Oral Cavity Squamous Cell Carcinoma |
title_short | Plasma Matrix Metalloproteinase-1 as a Prognostic Biomarker in Oral Cavity Squamous Cell Carcinoma |
title_sort | plasma matrix metalloproteinase-1 as a prognostic biomarker in oral cavity squamous cell carcinoma |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9762675/ https://www.ncbi.nlm.nih.gov/pubmed/36545225 http://dx.doi.org/10.2147/CMAR.S389742 |
work_keys_str_mv | AT tsaitsungyou plasmamatrixmetalloproteinase1asaprognosticbiomarkerinoralcavitysquamouscellcarcinoma AT kaohuangkai plasmamatrixmetalloproteinase1asaprognosticbiomarkerinoralcavitysquamouscellcarcinoma AT huangyenlin plasmamatrixmetalloproteinase1asaprognosticbiomarkerinoralcavitysquamouscellcarcinoma AT changyating plasmamatrixmetalloproteinase1asaprognosticbiomarkerinoralcavitysquamouscellcarcinoma AT youngchikuang plasmamatrixmetalloproteinase1asaprognosticbiomarkerinoralcavitysquamouscellcarcinoma AT hungshaoyu plasmamatrixmetalloproteinase1asaprognosticbiomarkerinoralcavitysquamouscellcarcinoma AT changyusun plasmamatrixmetalloproteinase1asaprognosticbiomarkerinoralcavitysquamouscellcarcinoma AT yujausong plasmamatrixmetalloproteinase1asaprognosticbiomarkerinoralcavitysquamouscellcarcinoma AT changkaiping plasmamatrixmetalloproteinase1asaprognosticbiomarkerinoralcavitysquamouscellcarcinoma |