Inhibition of mutant RAS-RAF interaction by mimicking structural and dynamic properties of phosphorylated RAS

Undruggability of RAS proteins has necessitated alternative strategies for the development of effective inhibitors. In this respect, phosphorylation has recently come into prominence as this reversible post-translational modification attenuates sensitivity of RAS towards RAF. As such, in this study,...

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Detalles Bibliográficos
Autores principales: Ilter, Metehan, Kasmer, Ramazan, Jalalypour, Farzaneh, Atilgan, Canan, Topcu, Ozan, Karakas, Nihal, Sensoy, Ozge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9762712/
https://www.ncbi.nlm.nih.gov/pubmed/36458814
http://dx.doi.org/10.7554/eLife.79747

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9762712/
https://www.ncbi.nlm.nih.gov/pubmed/36458814
http://dx.doi.org/10.7554/eLife.79747

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