Growth Hormone-Releasing Hormone Antagonist JV-1-36 Suppresses Reactive Oxygen Species Generation in A549 Lung Cancer Cells

Growth hormone-releasing hormone (GHRH) and its receptors are expressed in a variety of human cancers, and have been involved in malignancies. GHRH antagonists (GHRHAnt) were developed to suppress tumor progression and metastasis. Previous studies demonstrate the involvement of reactive oxygen speci...

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Autores principales: Kubra, Khadeja-Tul, Akhter, Mohammad S., Apperley, Kaitlyn, Barabutis, Nektarios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9762825/
https://www.ncbi.nlm.nih.gov/pubmed/36540765
http://dx.doi.org/10.3390/endocrines3040067
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author Kubra, Khadeja-Tul
Akhter, Mohammad S.
Apperley, Kaitlyn
Barabutis, Nektarios
author_facet Kubra, Khadeja-Tul
Akhter, Mohammad S.
Apperley, Kaitlyn
Barabutis, Nektarios
author_sort Kubra, Khadeja-Tul
collection PubMed
description Growth hormone-releasing hormone (GHRH) and its receptors are expressed in a variety of human cancers, and have been involved in malignancies. GHRH antagonists (GHRHAnt) were developed to suppress tumor progression and metastasis. Previous studies demonstrate the involvement of reactive oxygen species (ROS) in cancer progression. Herein, we investigate the effect of a commercially available GHRH antagonist, namely JV-1–36, in the redox status of the A549 human cancer cell line. Our results suggest that this peptide significantly reduces ROS production in those cells in a time-dependent manner and counteracts H(2)O(2)-induced ROS. Our study supports the anti-oxidative effects of JV-1–36 and contributes in our knowledge towards the in vitro effects of GHRHAnt in cancers.
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spelling pubmed-97628252022-12-19 Growth Hormone-Releasing Hormone Antagonist JV-1-36 Suppresses Reactive Oxygen Species Generation in A549 Lung Cancer Cells Kubra, Khadeja-Tul Akhter, Mohammad S. Apperley, Kaitlyn Barabutis, Nektarios Endocrines Article Growth hormone-releasing hormone (GHRH) and its receptors are expressed in a variety of human cancers, and have been involved in malignancies. GHRH antagonists (GHRHAnt) were developed to suppress tumor progression and metastasis. Previous studies demonstrate the involvement of reactive oxygen species (ROS) in cancer progression. Herein, we investigate the effect of a commercially available GHRH antagonist, namely JV-1–36, in the redox status of the A549 human cancer cell line. Our results suggest that this peptide significantly reduces ROS production in those cells in a time-dependent manner and counteracts H(2)O(2)-induced ROS. Our study supports the anti-oxidative effects of JV-1–36 and contributes in our knowledge towards the in vitro effects of GHRHAnt in cancers. 2022-12 2022-12-09 /pmc/articles/PMC9762825/ /pubmed/36540765 http://dx.doi.org/10.3390/endocrines3040067 Text en https://creativecommons.org/licenses/by/4.0/This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kubra, Khadeja-Tul
Akhter, Mohammad S.
Apperley, Kaitlyn
Barabutis, Nektarios
Growth Hormone-Releasing Hormone Antagonist JV-1-36 Suppresses Reactive Oxygen Species Generation in A549 Lung Cancer Cells
title Growth Hormone-Releasing Hormone Antagonist JV-1-36 Suppresses Reactive Oxygen Species Generation in A549 Lung Cancer Cells
title_full Growth Hormone-Releasing Hormone Antagonist JV-1-36 Suppresses Reactive Oxygen Species Generation in A549 Lung Cancer Cells
title_fullStr Growth Hormone-Releasing Hormone Antagonist JV-1-36 Suppresses Reactive Oxygen Species Generation in A549 Lung Cancer Cells
title_full_unstemmed Growth Hormone-Releasing Hormone Antagonist JV-1-36 Suppresses Reactive Oxygen Species Generation in A549 Lung Cancer Cells
title_short Growth Hormone-Releasing Hormone Antagonist JV-1-36 Suppresses Reactive Oxygen Species Generation in A549 Lung Cancer Cells
title_sort growth hormone-releasing hormone antagonist jv-1-36 suppresses reactive oxygen species generation in a549 lung cancer cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9762825/
https://www.ncbi.nlm.nih.gov/pubmed/36540765
http://dx.doi.org/10.3390/endocrines3040067
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