A Study to Investigate the Role of Noncoding RNA miR146 Alpha as a Potential Biomarker in Prostate Cancer

There is a need for additional biomarkers for the diagnosis and prognosis of prostate cancer. MicroRNAs are a class of non-protein coding RNA molecules that are frequently dysregulated in different cancers including prostate cancer and show promise as diagnostic biomarkers and targets for therapy. H...

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Detalles Bibliográficos
Autores principales: Worthington, Myla, Aurelus, Chelsey, Banerjee, Narendra, Krauss, Christopher, Kahan, William, Banerjee, Satyendra, Gavin, Sherita, Bartlett, Victoria, Payne, Gloria, Rousch, Jeffrey, Verma, Mukesh, Sarkar, Fazlul, Banerjee, Hirendra Nath
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9762859/
https://www.ncbi.nlm.nih.gov/pubmed/36540895
http://dx.doi.org/10.30683/1927-7229.2022.11.03
Descripción
Sumario:There is a need for additional biomarkers for the diagnosis and prognosis of prostate cancer. MicroRNAs are a class of non-protein coding RNA molecules that are frequently dysregulated in different cancers including prostate cancer and show promise as diagnostic biomarkers and targets for therapy. Here we describe the role of micro RNA 146 a (miR-146a) which may serve as a diagnostic marker for prostate cancer, as indicated from the data presented in this report. Also, a pilot study indicated differential expression of miR-146a in prostate cancer cell lines and tissues from different racial groups. This report provides a novel insight into understanding the prostate carcinogenesis.

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