A Study to Investigate the Role of Noncoding RNA miR146 Alpha as a Potential Biomarker in Prostate Cancer

There is a need for additional biomarkers for the diagnosis and prognosis of prostate cancer. MicroRNAs are a class of non-protein coding RNA molecules that are frequently dysregulated in different cancers including prostate cancer and show promise as diagnostic biomarkers and targets for therapy. H...

Descripción completa

Detalles Bibliográficos
Autores principales: Worthington, Myla, Aurelus, Chelsey, Banerjee, Narendra, Krauss, Christopher, Kahan, William, Banerjee, Satyendra, Gavin, Sherita, Bartlett, Victoria, Payne, Gloria, Rousch, Jeffrey, Verma, Mukesh, Sarkar, Fazlul, Banerjee, Hirendra Nath
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9762859/
https://www.ncbi.nlm.nih.gov/pubmed/36540895
http://dx.doi.org/10.30683/1927-7229.2022.11.03
_version_ 1784852938088251392
author Worthington, Myla
Aurelus, Chelsey
Banerjee, Narendra
Krauss, Christopher
Kahan, William
Banerjee, Satyendra
Gavin, Sherita
Bartlett, Victoria
Payne, Gloria
Rousch, Jeffrey
Verma, Mukesh
Sarkar, Fazlul
Banerjee, Hirendra Nath
author_facet Worthington, Myla
Aurelus, Chelsey
Banerjee, Narendra
Krauss, Christopher
Kahan, William
Banerjee, Satyendra
Gavin, Sherita
Bartlett, Victoria
Payne, Gloria
Rousch, Jeffrey
Verma, Mukesh
Sarkar, Fazlul
Banerjee, Hirendra Nath
author_sort Worthington, Myla
collection PubMed
description There is a need for additional biomarkers for the diagnosis and prognosis of prostate cancer. MicroRNAs are a class of non-protein coding RNA molecules that are frequently dysregulated in different cancers including prostate cancer and show promise as diagnostic biomarkers and targets for therapy. Here we describe the role of micro RNA 146 a (miR-146a) which may serve as a diagnostic marker for prostate cancer, as indicated from the data presented in this report. Also, a pilot study indicated differential expression of miR-146a in prostate cancer cell lines and tissues from different racial groups. This report provides a novel insight into understanding the prostate carcinogenesis.
format Online
Article
Text
id pubmed-9762859
institution National Center for Biotechnology Information
language English
publishDate 2022
record_format MEDLINE/PubMed
spelling pubmed-97628592022-12-19 A Study to Investigate the Role of Noncoding RNA miR146 Alpha as a Potential Biomarker in Prostate Cancer Worthington, Myla Aurelus, Chelsey Banerjee, Narendra Krauss, Christopher Kahan, William Banerjee, Satyendra Gavin, Sherita Bartlett, Victoria Payne, Gloria Rousch, Jeffrey Verma, Mukesh Sarkar, Fazlul Banerjee, Hirendra Nath J Anal Oncol Article There is a need for additional biomarkers for the diagnosis and prognosis of prostate cancer. MicroRNAs are a class of non-protein coding RNA molecules that are frequently dysregulated in different cancers including prostate cancer and show promise as diagnostic biomarkers and targets for therapy. Here we describe the role of micro RNA 146 a (miR-146a) which may serve as a diagnostic marker for prostate cancer, as indicated from the data presented in this report. Also, a pilot study indicated differential expression of miR-146a in prostate cancer cell lines and tissues from different racial groups. This report provides a novel insight into understanding the prostate carcinogenesis. 2022 2022-07-22 /pmc/articles/PMC9762859/ /pubmed/36540895 http://dx.doi.org/10.30683/1927-7229.2022.11.03 Text en https://creativecommons.org/licenses/by/4.0/This is an open access article licensed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ) which permits unrestricted use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Worthington, Myla
Aurelus, Chelsey
Banerjee, Narendra
Krauss, Christopher
Kahan, William
Banerjee, Satyendra
Gavin, Sherita
Bartlett, Victoria
Payne, Gloria
Rousch, Jeffrey
Verma, Mukesh
Sarkar, Fazlul
Banerjee, Hirendra Nath
A Study to Investigate the Role of Noncoding RNA miR146 Alpha as a Potential Biomarker in Prostate Cancer
title A Study to Investigate the Role of Noncoding RNA miR146 Alpha as a Potential Biomarker in Prostate Cancer
title_full A Study to Investigate the Role of Noncoding RNA miR146 Alpha as a Potential Biomarker in Prostate Cancer
title_fullStr A Study to Investigate the Role of Noncoding RNA miR146 Alpha as a Potential Biomarker in Prostate Cancer
title_full_unstemmed A Study to Investigate the Role of Noncoding RNA miR146 Alpha as a Potential Biomarker in Prostate Cancer
title_short A Study to Investigate the Role of Noncoding RNA miR146 Alpha as a Potential Biomarker in Prostate Cancer
title_sort study to investigate the role of noncoding rna mir146 alpha as a potential biomarker in prostate cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9762859/
https://www.ncbi.nlm.nih.gov/pubmed/36540895
http://dx.doi.org/10.30683/1927-7229.2022.11.03
work_keys_str_mv AT worthingtonmyla astudytoinvestigatetheroleofnoncodingrnamir146alphaasapotentialbiomarkerinprostatecancer
AT aureluschelsey astudytoinvestigatetheroleofnoncodingrnamir146alphaasapotentialbiomarkerinprostatecancer
AT banerjeenarendra astudytoinvestigatetheroleofnoncodingrnamir146alphaasapotentialbiomarkerinprostatecancer
AT krausschristopher astudytoinvestigatetheroleofnoncodingrnamir146alphaasapotentialbiomarkerinprostatecancer
AT kahanwilliam astudytoinvestigatetheroleofnoncodingrnamir146alphaasapotentialbiomarkerinprostatecancer
AT banerjeesatyendra astudytoinvestigatetheroleofnoncodingrnamir146alphaasapotentialbiomarkerinprostatecancer
AT gavinsherita astudytoinvestigatetheroleofnoncodingrnamir146alphaasapotentialbiomarkerinprostatecancer
AT bartlettvictoria astudytoinvestigatetheroleofnoncodingrnamir146alphaasapotentialbiomarkerinprostatecancer
AT paynegloria astudytoinvestigatetheroleofnoncodingrnamir146alphaasapotentialbiomarkerinprostatecancer
AT rouschjeffrey astudytoinvestigatetheroleofnoncodingrnamir146alphaasapotentialbiomarkerinprostatecancer
AT vermamukesh astudytoinvestigatetheroleofnoncodingrnamir146alphaasapotentialbiomarkerinprostatecancer
AT sarkarfazlul astudytoinvestigatetheroleofnoncodingrnamir146alphaasapotentialbiomarkerinprostatecancer
AT banerjeehirendranath astudytoinvestigatetheroleofnoncodingrnamir146alphaasapotentialbiomarkerinprostatecancer
AT worthingtonmyla studytoinvestigatetheroleofnoncodingrnamir146alphaasapotentialbiomarkerinprostatecancer
AT aureluschelsey studytoinvestigatetheroleofnoncodingrnamir146alphaasapotentialbiomarkerinprostatecancer
AT banerjeenarendra studytoinvestigatetheroleofnoncodingrnamir146alphaasapotentialbiomarkerinprostatecancer
AT krausschristopher studytoinvestigatetheroleofnoncodingrnamir146alphaasapotentialbiomarkerinprostatecancer
AT kahanwilliam studytoinvestigatetheroleofnoncodingrnamir146alphaasapotentialbiomarkerinprostatecancer
AT banerjeesatyendra studytoinvestigatetheroleofnoncodingrnamir146alphaasapotentialbiomarkerinprostatecancer
AT gavinsherita studytoinvestigatetheroleofnoncodingrnamir146alphaasapotentialbiomarkerinprostatecancer
AT bartlettvictoria studytoinvestigatetheroleofnoncodingrnamir146alphaasapotentialbiomarkerinprostatecancer
AT paynegloria studytoinvestigatetheroleofnoncodingrnamir146alphaasapotentialbiomarkerinprostatecancer
AT rouschjeffrey studytoinvestigatetheroleofnoncodingrnamir146alphaasapotentialbiomarkerinprostatecancer
AT vermamukesh studytoinvestigatetheroleofnoncodingrnamir146alphaasapotentialbiomarkerinprostatecancer
AT sarkarfazlul studytoinvestigatetheroleofnoncodingrnamir146alphaasapotentialbiomarkerinprostatecancer
AT banerjeehirendranath studytoinvestigatetheroleofnoncodingrnamir146alphaasapotentialbiomarkerinprostatecancer

Ejemplares similares