Analysis of hyperforin (St. John’s wort) action at TRPC6 channel leads to the development of a new class of antidepressant drugs

St. John’s wort is an herb, long used in folk medicine for the treatment of mild depression. Its antidepressant constituent, hyperforin, has properties such as chemical instability and induction of drug-drug interactions that preclude its use for individual pharmacotherapies. Here we identify the tr...

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Detalles Bibliográficos
Autores principales: El Hamdaoui, Yamina, Zheng, Fang, Fritz, Nikolas, Ye, Lian, Tran, Mai Anh, Schwickert, Kevin, Schirmeister, Tanja, Braeuning, Albert, Lichtenstein, Dajana, Hellmich, Ute A., Weikert, Dorothee, Heinrich, Markus, Treccani, Giulia, Schäfer, Michael K. E., Nowak, Gabriel, Nürnberg, Bernd, Alzheimer, Christian, Müller, Christian P., Friedland, Kristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9763113/
https://www.ncbi.nlm.nih.gov/pubmed/36224261
http://dx.doi.org/10.1038/s41380-022-01804-3

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